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Antibiotic Delivery System for Dental Pulp

Shahmoradi, Elnaz | 2019

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  1. Type of Document: M.Sc. Thesis
  2. Language: Farsi
  3. Document No: 54959 (06)
  4. University: Sharif University of Technology
  5. Department: Chemical and Petroleum Engineering
  6. Advisor(s): Abdekhodaie, Mohammad Jafari; Nekoofar, Mohammad Hossein
  7. Abstract:
  8. A triple antibiotic mixture (ciprofloxacin, metronidazole, and minocycline) has been used for dental root canal medicaments in pulp regeneration therapy. However, tooth discolorations, cervical root fractures, and inadequate pulp-dentin formation have been reported due to the triple antibiotic regimen. Therefore, antibiotic containing scaffold has been developed to minimize the clinical limitations and maximize a natural healing process in root canal infections. The ideal controlled release drug device should have the following characteristics. It should not degrade inside the root canal and it should be easily inserted into and removed from the root canal. In addition, the drug should be released continuously for a controlled time period.In this study, a controlled release system for metronidazole and ciprofloxacin has been presented. Effects of formulation parameters on fractional release profile of this antibiotics from matrices heve been studied. Hot melt extrusion method was used to fabricate scaffolds. A relatively steady release rate for over 21 days after an initial burst was achieved, which is desirable for establishing and maintaining the necessary therapeutic levels. Ultimately, the ability of scaffolds to deliver intracanal, uniform, and greatly controlled amounts of antibiotics may have positive treatment implications by providing a bacteria-free environment conducive to tissue regeneration, while minimizing the adverse effects of toxicity currently associated with the use of the antibiotic paste. In sum, our antibiotic-containing scaffolds hold promise for the improvement of current regenerative strategies by providing a drug delivery system to disinfect necrotic immature permanent teeth through a controllable release of low, yet effective, antibiotic doses when compared with conventional treatments
  9. Keywords:
  10. Antibiotic ; Extended Release System ; Dentistry ; Metronidasole ; Ciprofloxacin Antibiotic ; Dental Pulp

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