Loading...

Controlled Release Delivery System for Antibiotic in Bone Cement

Beyki Sarve ol’ya, Mohammad Saeed | 2021

296 Viewed
  1. Type of Document: M.Sc. Thesis
  2. Language: Farsi
  3. Document No: 55024 (06)
  4. University: Sharif University of Technology
  5. Department: Chemical and Petroleum Engineering
  6. Advisor(s): Abd Khodaei, Mohammad Jafar
  7. Abstract:
  8. The incidence of skeletal diseases such as osteoarthritis and its progression and the need to use knee replacement implants have significant effects on the quality of life. With the improvement of living conditions and the prolongation of the average life expectancy of the society and the aging of a large part of the society, the concern about the increase in the incidence of skeletal diseases and the need to use alternative implants increases. On the other hand, many conditions such as osteoporosis and accidents lead to fractures and cavities in the bones. Bone cements are one of the most widely used materials in orthopedic and spinal surgeries.The aim of this study was to construct a suitable antibiotic release system in bone cement with approved properties of ASTM F-451 and ISO5833 for orthopedic applications including joint replacement. In this regard, polymethyl methacrylate polymer as the main component of bone cement powder was synthesized from methyl methacrylate monomer by free radical polymerization, and its properties were evaluated by structural tests of HNMR, FTIR, and DSC as well as temperature tests.Calcium phosphate mineral cements were used as carriers for the antibiotic gentamicin. For this purpose, four cements of nano-hydroxyapatite, alpha and beta-tricalcium phosphate, and tetra calcium phosphate were synthesized by dry method and its properties were evaluated by SEM and XRD tests.After performing a release test for 42 days, it was concluded that the use of carriers has a significant role in increasing and improving the release rate of antibiotics by at least more than 3 times without carriers of polymethyl methacrylate bone cement samples
  9. Keywords:
  10. Poly Methylmethacrylate ; Calcium Phosphate ; Controlled Release ; Antibiotic ; Injectable Bone Cement ; Bone Implant

 Digital Object List

 Bookmark

No TOC