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Continuous Catalytic Synthesis of Medicine Through a Micro-Reactor System

Jahangirifard, Shayan | 2022

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  1. Type of Document: M.Sc. Thesis
  2. Language: Farsi
  3. Document No: 55206 (06)
  4. University: Sharif University of Technolog
  5. Department: Chemical and Petroleum Engineering
  6. Advisor(s): Kazemeini, Mohammad; Hosseinpour, Vahid
  7. Abstract:
  8. In the past decades, the production of various active pharmaceutical ingredients in batch processes was common. But today, the approach of pharmaceutical companies has changed and the use of the equipment and continuous processes such as microreactors has become common for reasons of safety, better mass and heat transfer, reduction of operators, and ease of scale-up. Unlike many top-selling drugs such as Ibuprofen and Artemisinin, Clopidogrel, the world's third best-selling drug needed by cardiac patients, has been manufactured only in batch processes. Due to the increase in the average age of the population, the urgent need for the use of Plavix (clopidogrel) has increased in recent years. In this study, we first fabricated glass microchips for drug production. Then, the production of clopidogrel in continuous systems was studied by changing parameters such as temperature, flow rate, residence time, and solvent, resulting in a yield of 58.2% in 40 minutes and 50°C. Due to the need to increase mass transfer in these systems and to ensure complete continuity of the process, the micromixer with deformable baffles was simulated using Comsol software. At different Reynolds numbers, the parameters of baffle width, length baffle and the number of mixing units were studied to obtain the mixing Index and pressure drop. At low Reynolds numbers, the mixing parameter reached about 60%, while at 50 Reynolds numbers it reached about 98%, which is a significant value for drug synthesis
  9. Keywords:
  10. Microreactor ; Micromixer ; Computational Fluid Dynamics (CFD) ; Drug Synthesis ; Continuous Processes ; Plavix Drug

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