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Effect of Urease on the Motion of Janus Micromotors Based on Black Titanium Dioxide

Hassani, Atefeh | 2022

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  1. Type of Document: M.Sc. Thesis
  2. Language: Farsi
  3. Document No: 55207 (07)
  4. University: Sharif University of Technolog
  5. Department: Materials Science and Engineering
  6. Advisor(s): Madaah Hosseini, Hamid Reza
  7. Abstract:
  8. The bladder is one of the most important internal organs of human that improper functioning of this organ causes various diseases such as bladder exstrophy, bladder syndrome, bladder cancer and bladder infection. The main challenge in treating these diseases is the presence of a mucous layer consisting of glycosaminoglysis (GAG) in the bladder wall that prevents drugs from reaching the surface of the bladder. Hence, drug delivery through the mucosal layer is not easy, Hence, urease micro/nano carriers have recently been considered for the treatment of bladder diseases. In this study, new janus micromotors based on black titanium oxide with asymmetric urease catalytic coating were synthesized in order to benefit from the antibacterial properties of black titanium oxide under infrared light and motion in simulated bladder (urea) environments. The path of these micromotors in environments containing (water and urea), (Phosphate-buffered saline and urea), (sodium chloride and urea salt) and urine to identify the effect of parameters such as the amount of urease enzyme on the surface of micromotors, fuel concentration or urea, viscosity and Ions were investigated on the speed of micromotors. In all the mentioned environments, the maximum speed (33.09 μm/s) was related to the micromotors on which the enzyme urease was placed in several layers. The velocity of multilayer micromotors was reduced from 33.09 μm/s in water and urea to 15.34 μm/s in sodium chloride and urea. This significant reduction in the motility of micromotors in ion-containing environments indicates that the predominant mechanism of motion of these enzymatic micromotors is the mechanism of self-diffusiophoresis
  9. Keywords:
  10. Bladder ; Janus Micromotor ; Enzymatic Micromotors ; Black Titanium Dioxide ; Urease ; Janus Nanoparticles

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