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Fabrication of Conductive Electrospun Fibers for Smart Drug Delivery

Khanjari, Jafar | 2021

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  1. Type of Document: M.Sc. Thesis
  2. Language: Farsi
  3. Document No: 55325 (07)
  4. University: Sharif University of Technology
  5. Department: Materials Science and Engineering
  6. Advisor(s): Nemati, Ali; Simchi, Abdolreza
  7. Abstract:
  8. In tissue engineering and nerve cell treatments, biocompatible and conductive substrates are needed to stimulate nerve cells. In this project, we fabricated a composite of polyaniline and gelatin along with metal-organic frameworks and graphene quantum dots, which perform this repair process for us. For this purpose, we used polyaniline. Due to its conductivity, this polymer stimulates the nervous tissue and in this way, it can perform the repair work. By conducting UV-Vis and FTIR tests, it was observed that the synthesis of aniline polymer has been achieved successfully. SEM analysis showed that the polymer chains were well formed. The other part of the composite used is MOF (metal-organic frameworks), which provides a platform for drug loading, due to its porosity, and also controls the entry and exit of the drug. FTIR, XRD and SEM analyzes were used to characterize these metal-organic frameworks. Also, their porosity was evaluated using BET analysis. In this project, dexamethasone sodium phosphate was used as a drug, which plays an important role in tissue repair due to its effect on the cell membrane and making it flexible. After simultaneous loading of this drug during the synthesis of metal-organic frameworks, the release rate of the drug was investigated with the help of UV-Vis analysis.The last part of the composite used in this research is GQDs (Graphene Quantum Dots), which, due to its optical properties, helps us to examine the process of repairing biological tissues and the state of cells in biological imaging and monitoring. Absorption and emission properties of GQD were investigated by UV-Vis and Photoluminescence analysis. Finally, the composite was made in the form of porous fibers by electrospinning from the above components. Due to the low molecular weight of PANI, gelatin has been used for electrospinning synthesis. To overcome this problem, we used glutaraldehyde along with gelatin, which makes the structure stable. With the help of UV-Vis analysis, the amount of swelling and degradation of the electrospun samples was checked.
  9. Keywords:
  10. Nanofiber ; Conductive Polymer ; Electrospinning ; Polyaniline ; Metal-Organic Framework ; Graphene Quantum Dots (GQDs) ; Targeted Druy Delivery ; Tissue Engineering

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