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Assessment of expression of a number of immune-related genes in the periodontitis

Gholami, L ; Sharif University of Technology | 2022

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  1. Type of Document: Article
  2. DOI: 10.1016/j.egg.2021.100106
  3. Publisher: Elsevier Inc , 2022
  4. Abstract:
  5. Immune-related genes have essential roles in the pathobiology of periodontitis. In the current projects, we aimed at appraisal of the expression amounts of three immune-related genes including two mRNA coding genes (NR3C1 and CSTF2) and a long non-coding RNA (CCAT2) in tissue sections and blood of patients with this condition versus healthy controls. Our previous study has shown the susceptibility role of HLA-DRB1*04 allele in development of this disease. So the subjects who were positive for HLA-DRB1*04 allele were excluded. Expression amounts of CCAT2, NR3C1 and CSTF2 genes have been statistically similar between periodontitis patients and controls in both blood samples and tissue samples. Expression levels of CCAT2, NR3C1 and CSTF2 genes have been significantly correlated in blood samples as well as in tissue samples. However, there was no significant correlation between tissue and blood levels of each gene. Expression levels of CCAT2, NR3C1 and CSTF2 genes in blood or tissue sections could not appropriately distinguish patients with periodontitis from healthy subjects. The best AUC values have been displayed for CCAT2 and CSTF2 genes in blood samples (AUC = 0.71). Our study indicates that CCAT2, NR3C1 and CSTF2 genes are not important factors in the development of periodontitis and cannot be used as biomarkers for this condition. © 2021
  6. Keywords:
  7. CCAT2 ; NR3C1 and CSTF2 genes ; Periodontitis
  8. Source: Ecological Genetics and Genomics ; Volume 22 , 2022 ; 24059854 (ISSN)
  9. URL: https://www.sciencedirect.com/science/article/abs/pii/S2405985421000288