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Unraveling cancer metastatic cascade using microfluidics-based technologies

Hakim, M ; Sharif University of Technology | 2022

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  1. Type of Document: Article
  2. DOI: 10.1007/s12551-022-00944-8
  3. Publisher: Springer Science and Business Media Deutschland GmbH , 2022
  4. Abstract:
  5. Cancer has long been a leading cause of death. The primary tumor, however, is not the main cause of death in more than 90% of cases. It is the complex process of metastasis that makes cancer deadly. The invasion metastasis cascade is the multi-step biological process of cancer cell dissemination to distant organ sites and adaptation to the new microenvironment site. Unraveling the metastasis process can provide great insight into cancer death prevention or even treatment. Microfluidics is a promising platform, that provides a wide range of applications in metastasis-related investigations. Cell culture microfluidic technologies for in vitro modeling of cancer tissues with fluid flow and the presence of mechanical factors have led to the organ-on-a-chip platforms. Moreover, microfluidic systems have also been exploited for capturing and characterization of circulating tumor cells (CTCs) that provide crucial information on the metastatic behavior of a tumor. We present a comprehensive review of the recent developments in the application of microfluidics-based systems for analysis and understanding of the metastasis cascade from a wider perspective. © 2022, International Union for Pure and Applied Biophysics (IUPAB) and Springer-Verlag GmbH Germany, part of Springer Nature
  6. Keywords:
  7. Circulating tumor cells ; Homing ; Metastatic cascade ; Microfluidics ; Tumor microenvironment ; Androgen receptor ; Beta1 integrin ; Biological marker ; Chemokine receptor CXCR4 ; Collagen ; Collagen type 1 ; Dimeticone ; Elastomer ; Epithelial cell adhesion molecule ; Epithelial derived neutrophil activating factor 78 ; Fibronectin ; Gelatinase A ; Gelatinase B ; Hyaluronic acid ; Hydrogel ; Iron oxide nanoparticle ; Matrigel ; Matrix metalloproteinase ; Messenger RNA ; Oxygen ; Plerixafor ; Polymer ; Secondary lymphoid tissue chemokine ; Seprase ; Short hairpin RNA ; Stromal cell derived factor 1 ; Thyrotropin receptor ; Transforming growth factor beta1 ; Vasculotropin receptor ; Angiogenesis ; Basement membrane ; BEL-7402 cell line ; Blood brain barrier ; Blood sampling ; Bone marrow mesenchymal stem cell ; Brain cancer ; Breast cancer ; Caco-2 cell line ; Cancer growth ; Cancer tissue ; Cause of death ; Cell adhesion ; Cell culture ; Cell division ; Cell interaction ; Cell invasion ; Cell migration ; Cell motility ; Circulating tumor cell ; Coculture ; Colorectal cancer ; DNA sequencing ; Electrophoresis ; Endothelium cell ; Extracellular matrix ; Fibroblast ; Flow cytometry ; Fluorescence in situ hybridization ; Gene expression profiling ; Gene sequence ; Glioma ; High performance liquid chromatography ; HUVEC cell line ; Hypoxia ; Macrophage ; MCF-7 cell line ; MDA-MB-231 cell line ; Melanoma ; Metastasis ; Microfluidic analysis ; Molecular biology ; Nonhuman ; Nutritional deficiency ; Oxygen diffusion ; Phenotype ; Polymerase chain reaction ; Polymerization ; Primary tumor ; Prostate cancer ; Reverse transcription polymerase chain reaction ; Review ; Shear stress ; Systematic review
  8. Source: Biophysical Reviews ; Volume 14, Issue 2 , 2022 , Pages 517-543 ; 18672450 (ISSN)
  9. URL: https://link.springer.com/article/10.1007/s12551-022-00944-8