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A new approach for simultaneously improved osseointegration and antibacterial activity by electrochemical deposition of graphene nanolayers over titania nanotubes

Yahya Rahnamaee, S ; Sharif University of Technology | 2022

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  1. Type of Document: Article
  2. DOI: 10.1016/j.apsusc.2021.152263
  3. Publisher: Elsevier B.V , 2022
  4. Abstract:
  5. Simultaneous enhancement of osseointegration and bacterial infection prohibition through surface modifications is a challenging but promising approach to achieve durable implantation. To that end, we present a multifunctional surface coating composed of graphene nanolayers and hierarchical well-aligned TiO2 nanotubes with a nanoporous top layer (cRTNT). FESEM studies reveal tunable increasing island morphologies of graphene nanolayers (G) on cRTNT by a cyclic voltammetry process. XPS analysis shows that the enhanced interface chemistry is due to TiO2-carbon bonding. The roughness of the sample containing a medium amount of graphene, cRTNT-75%GO, was calculated ∼289 nm, which was 543% higher than the Ti6Al4V surface. ALP activity increases by more than 25% for cRTNT/GO samples compared to pure cRTNT. Fluorescent microscopy indicates an approximately 92% decrease in bacterial colony formation and up to 85% improvement in the number of bacteria per field on cRTNT with increasing graphene amount compared to the Ti-6Al-4V surface. Although the increasing amount of graphene up to 95% shows better antibacterial performance, it does not provide a proper surface for adhesion and growth of the bone cells. According to all bio-assays, the nanocomposite coating with a medium amount of graphene (cRTNT-75%G) is proposed as the best sample in terms of biological properties, including improving cell behavior and preventing infection. © 2021
  6. Keywords:
  7. Bactericidal surface ; Bone implant ; Nanotubes ; Bone ; Chemical analysis ; Chemical bonds ; Coatings ; Cyclic voltammetry ; Electrochemical deposition ; Reduction ; Ternary alloys ; Titanium alloys ; Titanium dioxide ; Anti-bacterial activity ; Bacterial infections ; Nano layers ; New approaches ; Osseointegration ; Surface coatings ; Surface-modification ; Titania nanotubes ; Graphene
  8. Source: Applied Surface Science ; Volume 580 , 2022 ; 01694332 (ISSN)
  9. URL: https://www.sciencedirect.com/science/article/abs/pii/S0169433221032918