Loading...

Synthesis and Characterization of the Multifunctional Fe3O4@Mn3O4-LCysteine-g-C3N4 QDs System as a Contrast Agent for Dual-Model Magnetic Resonance and Fluorescence Imaging

Moeini, Ali | 2023

60 Viewed
  1. Type of Document: M.Sc. Thesis
  2. Language: Farsi
  3. Document No: 56797 (07)
  4. University: Sharif University of Technology
  5. Department: Materials Science and Engineering
  6. Advisor(s): Madaah Hosseini, Hamid Reza; Khachatourian, Adrine Malek
  7. Abstract:
  8. Cancer is one of the most important problems that affects public health. If this disease is diagnosed quickly in the patient's body, it can be prevented and treated by determining the stage of the disease and establishing a treatment protocol. Magnetic resonance imaging (MRI) and fluorescence imaging (FI) are among the imaging methods. In order to increase the contrast of images, researchers have turned to the synthesis of materials under contrast agents, which improve diagnostic sensitivity. Synthesis of nanoparticles as multi-mode contrast agents can enhance imaging methods. In this research, the synthesis and characterization of the multifunctional Fe3O4-Mn3O4-LCysteine@g-C3N4 QDs system as a contrast agent for magnetic resonance and fluorescence imaging has been discussed. First, the magnetite nanoparticle was synthesized by the co-precipitation method, and then by the hydrothermal method, the magnetite-manganese oxide core-shell nanoparticle was synthesized. Then, it was mechanically covered by L-cysteine and finally decorated with graphite carbonitride quantum dots (g-C3N4 QDs). Using XRD and FTIR analyses, the correctness of the synthesis of the system, the phases formed, and the links created have been confirmed. Also, the morphology of this nanocomposite was examined by SEM, and the particle size was around 19-29 nm. The final nanocomposite has maintained its superparamagnetic property and has a saturation magnetization of about 13.94 emu/g. Also, the optical properties of the nanocomposite were investigated by photoluminescence spectroscopy and visible-ultraviolet spectroscopy, and the system is a good candidate for fluorescence imaging. Finally, to check the biocompatibility of nanoparticles, a cytotoxicity test using the L929 fibroblast cell line was used for three days, and this nanocomposite indicated good cell viability
  9. Keywords:
  10. Magnetic Resonance Imagin (MRI) ; Contrast Agents ; Superparamagnetic Iron Oxide Nanoparticle ; Graphitic Carbon Nitride ; Quantum Dot ; Fluorescence Imaging (FI)

 Digital Object List

 Bookmark

No TOC