Synthesis of Dispirocyclopentanebisoxindoles via Self-Domino Michael-Aldol Reactions

Please enable javascript in your browser.

Badpa, Sara | 2024

0 Viewed

Type of Document: M.Sc. Thesis
Language: Farsi
Document No: 57034 (03)
University: Sharif University of Technology
Department: Chemistry
Advisor(s): Matloubi Moghaddam, Firouz
Abstract:
An efficient and facile one-pot, multi-component reaction for the regio- and diastereoselective synthesis of novel dispirocyclopentanebisoxindoles has been reported by a reaction between phenyl-2- (triphenylphosphoranylidene)ethanone and isatin derivatives. The great advantages of this synthetic protocol are the minimal reaction steps, short reaction time, and operational simplicity. In consequence, a variety of new dispirocyclopentanebisoxindole derivatives with potential medicinal applications were synthesized through one-pot and multi-component reaction in high to excellent yields
Keywords:
Dispirooxindol ; Isatin ; Green Chemistry ; Diastereoselective ; Regioselectivity ; Multicomponent Reaction

No TOC