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Formulation and characterization of a novel oxidized alginate-gelatin-silk fibroin bioink with the aim of skin regeneration

Sanaei, K ; Sharif University of Technology | 2023

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  1. Type of Document: Article
  2. DOI: 10.52547/ibj.3981
  3. Publisher: Pasteur Institute of Iran , 2023
  4. Abstract:
  5. Background: In the present study, a novel bioink was suggested based on the OAlg, GL, and SF hydrogels. Methods: The composition of the bioink was optimized by the rheological and printability measurements, and the extrusion-based 3D bioprinting process was performed by applying the optimum OAlg-based bioink. Results: The results demonstrated that the viscosity was continuously decreased by increasing the SF/GL ratio, but the bioink displayed a maximum achievable printability (92 ± 2%) at 2% (w/v) of SF and 4% (w/v) of GL. Moreover, the cellular behavior of the scaffolds investigated by MTT and live/dead assays confirmed the biocompatibility of the prepared bioink. Conclusion: The bioprinted OAlg-GL-SF scaffold may be explored further to have potential for applying in skin tissue engineering applications. © 2023, Pasteur Institute of Iran. All rights reserved
  6. Keywords:
  7. Alginate ; Bioprinting ; Fibroin ; Gelatin
  8. Source: Iranian Biomedical Journal ; Volume 27, Issue 5 , 2023 ; 1028852X (ISSN)
  9. URL: https://ibj.pasteur.ac.ir/article-1-3981-fa.html