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A review of magnesium corrosion in bio-applications: mechanism, classification, modeling, in-vitro, and in-vivo experimental testing, and tailoring Mg corrosion rate

Zhao, S ; Sharif University of Technology | 2023

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  1. Type of Document: Article
  2. DOI: 10.1007/s10853-023-08782-z
  3. Publisher: Springer , 2023
  4. Abstract:
  5. Materials with medical applications must show different properties and requirements, such as mimicking bones' structures and supporting bone tissue formation (osteogenesis) for implants. Magnesium (Mg) alloys as biodegradable materials have recently become outstanding biomaterials because of their desirable properties like being soluble within the body, having low density, exhibiting near-to-natural-bone Young module, and having after-corrosion-based products, which are not only biologically degradable but also non-toxic. In addition to the mentioned properties, the ability to stimulate new bone growth and more outstanding biocompatibility of Mg alloys than other ceramic-based, polymeric, and metallic biomaterials make Mg alloys one of the most favorable biomaterials for the next generation of orthopedic appliances and bioresorbable scaffolds. However, the rapid corrosion rate of Mg results in adverse outcomes such as hydrogen gas release (hydrogen built-up), mechanical integrity loss of the implant before the complete healing of the tissue (premature mechanical integrity disintegration), and weaker mechanical properties, which can limit their more comprehensive applications and restrict their ability in clinical bone restoration has become a challenge needing urgent action. The properties of Mg and its alloys, making them biomaterials and their applications, are introduced thoroughly in this study. At the same time, the most notable drawback of Mg, which is its rapid degradation rate, as well as Mg corrosion classification, its modeling approaches, and in vivo/in vitro testing methods, are fully described. Moreover, the relevant techniques to improve and boost its corrosion resistance, such as purification, adding alloying elements, surface coating, and Mg-based composites, are entirely presented. © 2023, The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature
  6. Keywords:
  7. Magnesium corrosion ; In-vivo experimental testing ; Biodegradable materials ; Mechanical properties ; In-vitro
  8. Source: Journal of Materials Science ; Volume 58, Issue 30 , 2023 , Pages 12158-12181 ; 00222461 (ISSN)
  9. URL: https://link.springer.com/article/10.1007/s10853-023-08782-z