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Improving cell proliferation using polylactic acid, polycaprolactone, hydroxyapatite and zinc oxide nanocomposite for cancellous bone substitutes

Dehghani Firoozabadi, F ; Sharif University of Technology | 2023

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  1. Type of Document: Article
  2. DOI: 10.1080/25740881.2023.2276775
  3. Publisher: Taylor and Francis Ltd , 2023
  4. Abstract:
  5. Different types of implants are used in orthopedic applications. Due to the stress shielding and a second surgery caused by applying metal implants as orthopedic joints, using biodegradable bone implants with antibacterial properties is advantageous. Therefore, this study aims at fabricating a multifunctional poly (lactic acid) (PLA)-polycaprolactone (PCL)-based scaffold reinforced with hydroxyapatite (HA) and zinc oxide (ZnO) nanoparticles. Solvent casting combined with die-casting techniques was employed for fabricating the scaffolds, and their physical, mechanical, and biological properties were characterized. The morphology of the samples and the growth of hydroxyapatite crystals on the surface of the samples were examined by field emission scanning electron microscope. In dry conditions, adding nanoparticles to the scaffolds has significantly (p <.05) increased the tensile Young’s modulus from 450.00 ± 87.18 MPa to 1050.66 ± 104.05 MPa. Also, adding ZnO has improved the antibacterial properties of the scaffolds against S.aureus and E.coli bacteria strains. Moreover, the MTT assay results (after 72 h cell culture) show that the viability of L929 cells has increased from 22.18 ± 0.62% for the PLA-PCL scaffold to 70.03 ± 0.25% for the optimal nanostructure (p <.05). In conclusion, the PCL-PLA/HA/1% ZnO scaffold could potentially be used as absorbable spongy bone implants. © 2023 Taylor & Francis
  6. Keywords:
  7. Hydroxyapatite ; Tissue-engineered scaffold ; Regenerative medicine ; Cytocompatibility ; Zinc oxide ; Antibacterial ; Cell proliferation antibacterial
  8. Source: Polymer-Plastics Technology and Materials ; Volume 63, Issue 2 , 2023 , Pages 95-119 ; 25740881 (ISSN)
  9. URL: https://www.tandfonline.com/doi/full/10.1080/25740881.2023.2276775