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- Type of Document: M.Sc. Thesis
- Language: Farsi
- Document No: 57644 (06)
- University: Sharif University of Technology
- Department: Chemical and Petroleum Engineering
- Advisor(s): Abdekhodaie, Mohammad Jafar
- Abstract:
- Wrinkles on the skin are among the most common effects of aging, which are associated with a decrease in the concentration of fibroblast cells and the breakdown of collagen and elastin chains. Youthfulness and skin beauty are important attributes of nature that are directly linked to human self-confidence, attracting numerous candidates each year for skin rejuvenation and restoration. Over the years, several non-invasive methods have been introduced to address wrinkles and increase the volume of subcutaneous tissue, with subdermal fillers emerging as an effective and safe approach commonly used in aesthetic clinics. Commercial fillers are categorized based on factors such as the base material used, duration of effectiveness, and injection depth in subcutaneous tissue. Hyaluronic acid possesses high water absorption properties and an exceptional ability to correct forehead wrinkles, under-eye hollows, nasolabial folds, neck lines, and lips, as well as to increase volume in targeted tissues. As it naturally exists in the human body, hyaluronic acid avoids issues related to biocompatibility and biodegradability. Hyaluronic acid fillers are classified as temporary fillers and require clinical re-injection approximately every six months, as the body's hyaluronidase enzyme degrades the polymeric chains of hyaluronic acid. Increasing the durability of fillers under the skin is a major challenge in designing these commercial products. Therefore, cross-linking through covalent bonding with materials and methods approved by the Food and Drug Administration (FDA) is used to enhance the mechanical strength of hydrogel fillers. In this study, micro-sized hydrogel particles of hyaluronic acid were synthesized with uniform spherical shapes using cross-linking with divinyl sulfone (DVS) to compare the injectability and mechanical strength of the samples. Additionally, the effect of increasing hyaluronic acid concentration on the degradability of the hydrogel filler was investigated. Hyaluronic acid microgels were created as injectable subdermal fillers using an electrodynamic device. The synthesized microgels were surface-modified with dopamine to increase adhesion to skin tissue, and ultimately, the samples demonstrated satisfactory results in cell viability assays
- Keywords:
- Microgel ; Hyaluronic Acid Gel ; Crosslinking ; Surface Modification ; Divinyl Sulfone ; Wrinkles
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