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Investigation and Simulation of Compton-Positron Emission Tomography Imaging System to Improve Image Quality

Daei Ghafur Basir, Fatemeh | 2024

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  1. Type of Document: M.Sc. Thesis
  2. Language: Farsi
  3. Document No: 57653 (46)
  4. University: Sharif University of Technology
  5. Department: Energy Engineering
  6. Advisor(s): Hosseini, Abolfazl; Niknami, Mostafa
  7. Abstract:
  8. The combination of Compton imaging and positron emission tomography, also known as Compton-PET, has gained attention due to its improved spatial resolution and imaging sensitivity compared to PET imaging alone. Compton-PET simulated system consists of two concentric detector rings. The inner ring with a smaller diameter is called the Compton scattering detector, the scatterer, and the outer ring, which has the dual applications of Compton scattering detection and PET detector, is called the absorber. Improving the images is possible by increasing resolution, contrast, and reducing noise, and the quality of nuclear medicine images also depends on these three characteristics. Considering the importance and many applications of PET imaging, in this research, we tried to achieve a better image output by increasing the spatial resolution by using the Compton-PET imaging approach and the simulation performed with GEANT4. In this simulation, the geometry of two detector rings, which consist of cubic crystals for the absorbing detector and the scattering detector inside the universe, was considered. The scattering detector ring is made of cubic crystals of LYSO material with a radius of 40 cm, the absorption detector geometry consists of cubic crystals of GAGG material. The volume of the universe is in the form of a cube with the dimensions of air. The gamma radiation source is that emits gamma rays with the energy of 511 keV was placed in the Micro-Derenzo phantom. In the research, the image reconstruction was done using the algorithm based on MLEM iteration. According to the results, the value of FWHM is reported as 2.896 mm. The energy resolution is equal to 5% at 511 keV so that the result can be directly validated and compared to NEMA standards
  9. Keywords:
  10. Scintillation Detector ; Spatial Resolution ; Maximum Likelihood-Expectation Maximization (MLEM) ; Geant4 Application for Tomographic (GATE)Emission ; Positron Emission Tomography (PET) ; Image Enhancement ; Compton-Positron Emission Tomography (PET)Imaging

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