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Polylactic Acid/Polyethylene Glycol/Cellulose Nanocrystals Composites

Ghodsi, Reza | 2024

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  1. Type of Document: M.Sc. Thesis
  2. Language: Farsi
  3. Document No: 57901 (06)
  4. University: Sharif University of Technology
  5. Department: Chemical and Petroleum Engineering
  6. Advisor(s): Frounchi, Masoud
  7. Abstract:
  8. Recent advancements in polymer science highlight the growing interest in enhancing polymeric materials with nanoparticles. These materials have extensive applications in tissue engineering, food packaging, and drug delivery due to their biodegradability, sustainable sourcing, and comparable properties to petroleum-based polymers.This study explores composites of polylactic acid, polyethylene glycol, and nanocrystalline cellulose for controlled ciprofloxacin release. Antibacterial activity was assessed through inhibition zone measurements, and cytotoxicity was evaluated using cell viability assays. Results demonstrated a direct correlation between drug release and antibacterial efficacy. Drug release profiles were obtained using an agar hydrogel matrix and in phosphate-buffered saline (pH = 7.4). The addition of CNC and PEG enhanced PLA's flexibility and accelerated drug release, with inhibition zone diameters increasing from 15 to 44 millimeters for Gram-positive bacteria.Characterization included Fourier-transform infrared spectroscopy to confirm interactions between drug and nanoparticles, and scanning electron microscopy and dynamic light scattering to analyze particle morphology and size, which averaged approximately 9 nanometers. Kinetic studies indicated that the Korsmeyer-Peppas model best describes the drug release behavior from the polymeric nanocarriers
  9. Keywords:
  10. Polylactic Acid ; Polyethylen Glycol (PEG) ; Cellulose Nanocrystal ; Ciprofloxacin Antibiotic ; Controlled Release ; Drug Release

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