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Covalent Attachment of Lysozyme Enzyme to Sulfur-Glycerol Copolymer for the Preparation of Proteinosome as a Hierarchical Structure

Heidari, Mohammad Mahdi | 2025

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  1. Type of Document: M.Sc. Thesis
  2. Language: Farsi
  3. Document No: 57994 (03)
  4. University: Sharif University of Technology
  5. Department: Chemistry
  6. Advisor(s): Kalhor, Hamid Reza
  7. Abstract:
  8. Hyperbranched copolymers are highly attractive due to their unique properties, such as tunable structure and surface functionality, making them versatile for applications in biotechnologies, pharmaceuticals, and materials engineering. Glycidol, as a reactive monomer with excellent biocompatibility, combined with sulfur, which enhances mechanical and chemical properties, represents a promising combination for hyperbranched copolymer synthesis. In this study, hyperbranched glycidol-sulfur copolymers were synthesized using cationic and anionic ring-opening polymerization methods. FT-IR analysis confirmed the successful incorporation of S-S bonds and sulfur-containing functional groups into the final polymer structure. HNMR and CNMR spectroscopy validated the chemical structure and indicated an increased sulfur content in the final copolymer. DLS and Zeta Potential analyses revealed that the resulting nanoparticles had suitable size and surface charge for potential biomedical applications. The successful conjugation of lysozyme with these copolymers further demonstrated their potential in biomedicine. Meanwhile, proteinosomes, as protein-polymer hybrid structures with advanced applications in drug delivery and enzymatic catalysis, remain an active area that could be applied to the prepared conjugation of lysozyme and polymer. This study demonstrates that the proposed synthetic approach can produce hyperbranched copolymers with controllable properties, suitable for a variety of applications
  9. Keywords:
  10. Sulfur ; Biomedical Applications ; Lysozyime ; Hyperbranched Copolymer ; Glycidol ; Proteinosome

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