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Synthesis of Red Phosphorus-Glycerol Copolymer and its Covalent Binding to Lysozyme Enzyme to Investigate the Structure and Function of the Enzyme within the Complex and CQD-Catalyzed Synthesis of Formamide Compounds

Salehi, Masumeh | 2025

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  1. Type of Document: M.Sc. Thesis
  2. Language: Farsi
  3. Document No: 58005 (03)
  4. University: Sharif University of Technology
  5. Department: Chemistry
  6. Advisor(s): Kalhor, Hamid Reza
  7. Abstract:
  8. Red phosphorus, due to its unique chemical properties, and glycidol, with its reactive functional groups, provide an effective combination for synthesizing new copolymers with potential applications in biological fields, particularly in enzyme stabilization. In this study, a novel copolymer was synthesized using red phosphorus and glycidol through an anionic ring-opening mechanism. The synthesis process was confirmed using various analytical techniques, including FTIR, NMR, and thermal analyses, which demonstrated the successful incorporation of functional groups and an average phosphorus content of 40% in the copolymer. In the next step, modification of this copolymer by linking it to the model enzyme lysozyme was proposed. This modification was designed to enhance the stability and efficiency of lysozyme under various biological conditions. Additionally, in a separate project, Carbon Quantum Dots (CQDs), which have recently emerged as promising catalysts in organic synthesis, were employed. In this study, the synthesis of formamide compounds, which are of significant importance, particularly in pharmaceutical applications, was investigated using these catalysts. A lysine-derived Carbon Quantum Dot (Lys-CQD) was employed as a metal-free catalyst for the transamidation reaction of aniline derivatives with dimethylformamide (DMF). In these reactions, DMF acted both as the carbonyl source and as the solvent, resulting in the stable synthesis of 11 formamide derivatives. The results demonstrated the efficiency of Lys-CQD in enhancing the reactivity of these compounds through green chemistry methods, as well as its remarkable recyclability, allowing it to be recovered and reused after the reaction
  9. Keywords:
  10. Glycidol ; Carbon Quantom Dots ; Lysine ; Polymer-Protein Conjugate ; Carbon Quantum Dot Catalysts ; Red Phosphorus

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