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Design, Synthesis, and Characterization of Biocompatible Nanocarriers Based on Metal–Organic Frameworks for Controlled Drug Delivery Systems

Daneshgar, Hossein | 2025

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  1. Type of Document: Ph.D. Dissertation
  2. Language: Farsi
  3. Document No: 58485 (03)
  4. University: Sharif University of Technology
  5. Department: Chemistry
  6. Advisor(s): Bagherzadeh, Mojtaba
  7. Abstract:
  8. The aim of this study was to design, synthesize, and characterize metal–organic framework (MOF)-based systems as multicomponent nanocarriers for drug delivery, employing green chemistry approaches, enhanced biocompatibility, and improved performance in controlled drug release. By adjusting the synthesis time of the MIL-125(Ti), samples with diverse pore sizes and specific surface areas were obtained, leading to the introduction of the concept of “sustainable surface and pore size” for drug delivery applications. The sample synthesized over 24 hours exhibited the highest specific surface area and pore volume, making it an excellent candidate for sustained drug release. Subsequently, A520 and MIL-88A-based nanocarriers were functionalized with bioactive molecules for the delivery of doxorubicin (DOX). The incorporation of terpenoid compounds extracted from tangerine peel as green surface modifiers of A520 led to the formation of multilayered structures with a “valley–hill” morphology and surface channels, significantly enhancing drug delivery performance. The results demonstrated that these surface modifications enabled pH-responsive and controlled drug release, reduced cytotoxicity, and improved biocompatibility. In the final phase, MIL-88A was further optimized by coating with trans-anethole (TA) molecules extracted from fennel, which confirmed the efficiency of this system for DOX delivery with intelligent biocompatibility. Various physicochemical characterization techniques, cytotoxicity assays, and drug release kinetics analyses were employed to evaluate the performance of the developed nanocarriers. Overall, this research provides new insights into the development of sustainable drug delivery systems based on MIL-125(Ti) and A520/MIL-88A nanocarriers with enhanced DOX loading and release performance. The findings highlight that combining green chemistry principles, structural property tuning, and the incorporation of bio-derived molecules can effectively improve the efficacy and safety of drug delivery systems. Moreover, the design rationale and analytical approaches employed in this study can be extended to other therapeutic delivery platforms
  9. Keywords:
  10. Green Chemistry ; Metal-Organic Framework ; Drug Delivery ; Controlled Release ; Nanocarrier

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