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    Fabricating Scaffold by Electrospinning with Natural Polymers for Creating Skin Wound Dressings

    , M.Sc. Thesis Sharif University of Technology Yousefi Zowj, Farnaz (Author) ; Alemzadeh, Iran (Supervisor) ; Vosoughi, Manouchehr (Supervisor)
    Abstract
    Skin, the largest organ in the body, presents sophisticated functions for maintaining the structural integrity of the entire body. Skin can regulate the temperature of the body, protect the body against microorganisms, have a sensory function, and produce vitamin-D through UV exposure when in direct sunlight.Due to the self-healing property of skin tissue, skin can be repaired by itself. Nevertheless, if extensive skin loss happens, owing to diabetic ulcers or deep burns, skin will not be able to repair the wound by itself. Therefore, it will lose its functions, and the fabrication of a skin equivalent will be necessary. These skin equivalents will cover the wound, regenerate the native... 

    Biological Treatment of Dairy Wastewater (Anaerobic/Anoxic/Aerobic)

    , M.Sc. Thesis Sharif University of Technology Yaghoobinezhad, Farnaz (Author) ; Alemzadeh, Iran (Supervisor) ; Vosoughi, Manouchehr (Supervisor)
    Abstract
    In this research, start-up, performance and stability of a A2O system (Anaerobic/ Anoxic/ Oxic) combined with a Moving Bed Bio Reactor (MBBR), using Kaldnes packings, have been investigated in treating synthetic dairy wastewater. Also the effect of influent Chemical Oxygen Demand (COD), Hydroulic Retention Time (HRT) and Ruturn Activated Sludge (RAS) ratio on removing pollutants such as COD, Total Nitrogen and Total Phosphorous have been studied. The experiments have been designed using ‘Design Of Experiments’ software, and at the end the results have been optimized based on desired terms. The performance and capability of the reactor in removing pollutants in 8, 12 and 16 hours of HRT,... 

    Investigation and Characterization of Circulating tumor Cells (CTCs) by the Microfluidics Systems

    , M.Sc. Thesis Sharif University of Technology Yari, Alireza (Author) ; Vossoughi, Manoucher (Supervisor) ; Alemzadeh, Iran (Supervisor) ; Shamloo, Amir (Supervisor)
    Abstract
    Cancer is the second leading cause of death among humans as one of the major human concerns. More than 500,000 people die of cancer each year in the United States alone. Cancer mortality is mainly due to cancer metastasis. Metastasis is the escape of cancer cells from a primary tumor, the circulation of cells in the circulatory system (CTSs), the penetration of/from vessel wall, and the formation of a secondary tumor. It is still not clear how the cells survive in the circulatory system, along with the mechanical pressures and stresses that exist in the body's capillary channals. In this study, a microcirculation model for circulating cells with barriers was designed and constructed by the... 

    Folic Acid Microencapsulation

    , M.Sc. Thesis Sharif University of Technology Kiaeipour, Pegah (Author) ; Alemzadeh, Iran (Supervisor)
    Abstract
    Most natural folate derivatives are highly sensitive to temperature, oxygen and light and their stability depends on food process condition. Alginate and pectin were evaluated for folic acid encapsulation and increasing its stability. By combining them and optimising encapsulation condition the efficiency was enhanced up to 90% . Furthermore, using polymers in combined form caused decrease in folic acid leakage from capsules in acidic condition of stomach. First of all, the time of encapsulation was measured which was 140-180 minutes. In this study the effect of Calcium Chloride concentration on encapsulation was studied. Therefore, two variables were selected which were pectin to algine... 

    Improvement of Edible Oil by Interestrification Process by Lipase

    , M.Sc. Thesis Sharif University of Technology Kouchak Yazdi, Zahra (Author) ; Alemzadeh, Iran (Supervisor) ; Razavi, Jalil (Supervisor)
    Abstract
    Fats and oils are one of the main human food diet components that provide the necessary fatty acids for our body. So the fatty acids available in consuming oils are so important. In this research the mixture of palm and sunflower oils with different compounds: (80:20, 60:40, 50:50, 40:60, 20:80) were used for preparing free- trans shortening by interesterification. For this purpose a special stabilized lipase (Lipozyme TLIM) were used and performed the physicochemical properties: free fatty acids, peroxide value, iodine value, slip melting point, solid fat content, P-anisidine value, soap, oxidative stability at 110 0C, and the profile of fatty acids on the primitive blends and final samples... 

    Mechanisms of Conjugated Linoleic acid and Enriched Glycerides Production as Neutraceuticals Food

    , Ph.D. Dissertation Sharif University of Technology Kouchak Yazdi, Zahra (Author) ; Alemzadeh, Iran (Supervisor) ; Vossughi, Manochehr (Co-Advisor)
    Abstract
    Dietary CLA production for medicinal purposes needs a safe and selective process. Biological production methods meet this goal. In this study, the microbial species that was suitable for CLA production was selected; then the CLA produced by bioconversion methods was utilized to produce CLA-enriched triglycerides by trans-esterification. Also the biochemical kinetics of CLA production and esterification reactions to produce CLA-enriched triglycerides was studied. In the presence of two substrates, the kinetics of enzymatic reaction was studied. Then the factors influencing on the microbial yield and CLA production including reaction conditions (reaction time, cell concentration and substrate... 

    Experimental Investigation and Modeling of Ferrous Biooxidation in a Monolithic Bioreactor

    , Ph.D. Dissertation Sharif University of Technology Kahrizi, Ehsan (Author) ; Vossoughi, Manoochehr (Supervisor) ; Alemzadeh, Iran (Supervisor)
    Abstract
    The bio-oxidation of ferrous iron is a potential industrial process in the regeneration of ferric iron and the removal of H2S in combustible gases. Bio-oxidation of ferrous iron may be an alternative method of producing ferric sulfate, which is a reagent used for removal of H2S from biogas, tail gas and pulp and paper industry. For practical use of this process, this study evaluated the optimal pH and initial ferric concentration. pH control looks like a key factor as it acts both on growth rate and on solubility of materials in the system. Some process variables such as pH and amount of initial ferrous ions on oxidation by A. ferrooxidans and the effects of such process variables dilution... 

    Evaluation of Process Partitioning of Enzyme in Polymer-Salt Aqueous Two-PHase Systems

    , M.Sc. Thesis Sharif University of Technology Kamankesh, Amin (Author) ; Alamzadeh, Iran (Supervisor) ; Vossoughi, Manouchehr (Supervisor) ; Pazuki, Gholamreza (Supervisor)
    Abstract
    In this research, the amount of partitioning Invertase to be evaluated in nine systems, these systems contain Peg 2000,Peg 4000 & Peg 6000 with three different salt.In first, Binodal curve for nine systems to be drown by cloudy point method, then five point be selected in each system such as sample feed. Invertase in every systems to be solved in constant weight fraction. The analysis of every phasesto be achieved by Merchuk method. For correlation data of this method to be used by Othmer-Tobias method and then using equation Mrchvk ensure the accuracy of phase analysis , analysis of the results obtained with the UV method was studied.Accuracy of UV analysis was studied by using lattice... 

    Preperation and Properties of Biodegradable Nanocomposites Packaging Films

    , M.Sc. Thesis Sharif University of Technology Pourkhanali Jirandehi, Khadijeh (Author) ; Alemzadeh, Iran (Supervisor) ; Vossoughi, Manoochehr (Supervisor)
    Abstract
    Increasing use of polymeric materials, especially in the packaging industry, besides the problems that exist in recycling these materials, has become a serious concern for the environment. The synthetic polymers are used widely in packaging industry so they have a considerable role in waste production in packaging industry. One way to solve this problem is adding a natural polymer to the synthetic polymer, as a result it becomes friendly environmentally. Starch is one of these natural polymers which is cheap and has the ability to complete degradation in the environment.using row starch in the polymeric compounds causes a severe drop in compound’s properties. For this reason, row starch must... 

    Mint Flavor Immobilization and Properties Determination

    , M.Sc. Thesis Sharif University of Technology Pakzad, Hadiseh (Author) ; Alemzadeh, Iran (Supervisor) ; Kazemi, Akhtarelmolook (Supervisor)
    Abstract
    Peppermint oil is one of the most often used food ingredients and it is volatile. Many common procedures such as microencapsulation have been used for protecting volatile food ingredients. For this research, L-menthol was chosen as the core material to be encapsulated. L-menthol is responsible for the minty flavor and cooling sensation of food and pharmaceutical products. The encapsulation of L-menthol was prepared by complex coacervation, using gum Arabic and gelatin as wall material and tannic acid as cross-linking agent. The effect of various processing parameters, including wall material, core material, tannic acid and tween¬80 concentrations, on particle size and efficiency was... 

    Co-microencapsulation of Probiotic Bacteria and DHA Fatty Acid; Optimization and Evaluation of the Viability of Probiotic and Oxidative Stability of DHA during Gastrointestinal Tract

    , M.Sc. Thesis Sharif University of Technology Vaziri, Asma Sadat (Author) ; Alemzadeh, Iran (Supervisor) ; Vossoughi, Manouchehr (Supervisor)
    Abstract
    Due to the increased public awareness about the role of food on health, an increased interest of consuming fortified food has grown rapidly. Probiotic bacteria and DHA poly-unsaturated fatty acid are two major bioactive ingredients becoming increasingly popular in food fortification industry due to their beneficial effects. However, high susceptibility of probiotic bacteria during production, maintenance and digestion in acidic and enzymatic conditions of gastrointestinal tract results in decreasing the survivability and therefore reducing health effects in body. Besides, having multiple double bonds in the structure of DHA fatty acid leads to oxidative degradation that produces volatile... 

    Enzyme Immobilization on Biopolymer Carrier by Microencapsulation Technique

    , M.Sc. Thesis Sharif University of Technology Hemmati, Mostafa (Author) ; Aalemzadeh, Iran (Supervisor) ; Vossoughi, Manouchehr (Supervisor)
    Abstract
    β-galactosidase enzyme is immobilized from Kluyveromyces lactis by Microencapsulation method in various compositions of sodium alginate and Carboxymethyl cellulose. Optimum stabilization was gained at 1.85% sodium alginate, 0.9% carboxymethyl cellulose and 2% calcium chloride through applying Surface response methodology. Yield of immobilization and activity was 54.94% and 65.27%. variation of yield of immobilization versus alginate concentration was a quadratic curve with the maximum. When alginate's concentrations is low, the cavities diameter is great, so the enzyme leaks from capsule while immobilizing. At high concentrations of alginate, despite the smaller cavities, immobilization... 

    Study and Synthesis of Biocompatible Polymer and Loading of Peptide Drug for using in Drug Delivery

    , M.Sc. Thesis Sharif University of Technology Nikravesh, Niusha (Author) ; Vosoughi, Manouchehr (Supervisor) ; Alemzadeh, Iran (Co-Advisor)
    Abstract
    With the rapid development of biotechnology, peptide and protein drugs are now playing an increasingly important role in therapeutics. Compared with chemical drugs, peptide and protein drugs have some limitations such as low stability and rapid deactivation. Biodegradable and biocompatible polymeric micro carriers have been shown to have a high potential for the delivery of peptides and proteins. Among these polymers, alginate has been widely investigated as a biomaterial. Alginates are natural polysaccharide polymers isolated from brown seaweed. Bovine serum albumin (BSA) loaded calcium alginate microspheres produced in this study by a modified w/o emulsification method. The influence of... 

    The Application of Nano Scale Iron Particle in Water Treatment

    , M.Sc. Thesis Sharif University of Technology Nikroo, Razieh (Author) ; Alem zadeh, Iran (Supervisor) ; Vosoughi, Manouchehr (Supervisor)
    Abstract
    Chlorinated hydrocarbons such as trichloroethylene form a kind of dense non-aqueous phase liquid contaminants in groundwater and soil that are so difficult to remediate. In recent years, many field research has been demonstrated application of nano scale zero valent iron can degrade these contaminants.
    In this research, nZVI particle synthesized by liquid phase reduction method. Nickel (25%wt ) has been added to increase the reduction rate and also reduce intermediate pollutions. However, the combination of a noble metal to nZVI, leads to more rapid oxidation and tendency to agglomeration. So nZVI particles coated by applying a water soluble-starch solution (0.4%wt) as a stabilizer. The... 

    Immobilization of Enzymes to Nanoparticles for use in Wastewater Treatment

    , M.Sc. Thesis Sharif University of Technology Nisan, Roya Sadat (Author) ; Alemzadeh, Iran (Supervisor)
    Abstract
    Nowadays , application of enzymes as biocatalysts in wastewater treatment processes is increasing. It is economically important to reuse enzymes and increase their stability in these types of processes. Therefore, was immobilization of enzymes and using them in wastewater treatment have a great importance.In this project, Horseradish peroxidase enzyme, whose effect on phenol removal reactions in other studies has been proven before, was immobilized on the alginate-coated magnetic nanoparticles, to investigate the effect of immobilization on the stability and function of this enzyme for phenol removal. The enzyme was immobilized at the temperature of 25 ° C and pH = 8, according to the data... 

    Optimization of Xylitol Production

    , M.Sc. Thesis Sharif University of Technology Nozari, Nafise (Author) ; Alemzade, Iran (Supervisor)
    Abstract
    Xylitol is a sugar alcohol or polyol that has been used as a food additive and sweetening agent due to Its high sweetening power, anti-cariogenic properties and possibilities for use in diabetic food products, makes xylitol an attractive sucrose substitute in a wide variety of foods and beverages. Xylitol is a five carbon polyol or pentitol obtained by the hydrogenation of xylose. xylitol could be produced from xylose in rice seed coats medium by Saccharomyces cerevisiae. For xylitol production, S.cerevisiae was grown in preculture medium at 30°C and agitated at 120 rpm on a rotary platform shaker. The cells were harvested after 20hr, were centrifuged and transferred to the production... 

    Comparative Examination and Preparation of Polymeric Hydrogels in Order to use as Cellular Scaffold

    , M.Sc. Thesis Sharif University of Technology Nazaripouya, Amir (Author) ; Alemzadeh, Iran (Supervisor) ; Sharifi Aghdas, Farzane (Supervisor) ; Mashayekhan, Shohre (Supervisor)

    Determination of Micro Encapsulation of Probiotic

    , M.Sc. Thesis Sharif University of Technology Najafizadeh, Mobarakeh (Author) ; Alemzadeh, Iran (Supervisor)
    Abstract
    Probiotics are defined as essential live microorganisms that, when administered in adequate amounts, confer a health benefit on the host. In order to provide health benefits for probiotic bacteria it has been recommended that they must be present at a minimum level of 106 CFU/g of food product or 107 CFU/g at point of delivery or be eaten in sufficient amounts to yield a daily intake of 108 CFU. Several studies have shown that certain strain of lactic acid bacteria, such as Bifidobacterium bifidum and Lactobacillus acidophilus prevent some diseases linked to the gastro-intestinal tract. however, many reports have demonstrated their poor survival and stability. Their survival in the... 

    Experimental Investigation on Growth and Control of Animal Cells Attached on Scaffold

    , M.Sc. Thesis Sharif University of Technology Solmaz, Naseri (Author) ; Vossoughi, Manoochehr (Supervisor) ; Alamzadeh, Iran (Co-Advisor)
    Abstract
    Major bone defects resulted from diseases or hurts that can not heal naturally, requaire bone transplantation. golden standard for transplantation is autologus one but it has some disad-vantages such as economic burden, the lack of graft source, surgery on patient, and so on. so exploring altrnative ways led to exploit stem cells.traditionally bone marrow mesenchymal stem cells (MSCs) used for stem cell-bsaed bone regeneration. bone marrow aspiration to aquaire stem cells is painfull and give a population of cells such as hematopoetic cells that requaire to seperate and can not be handled in first passages. MSCs can be substituted by multipotent adipose tissue-derived stem cells (ADSCs) in... 

    Simulation, Evaluation and Fabrication of a Two-step Microfluidic System to Separate Circulating Tumor Cells

    , M.Sc. Thesis Sharif University of Technology Mir Mohammad Sadeghi, Fatemeh Sadat (Author) ; Vosoughi, Manouchehr (Supervisor) ; Alamzadeh, Iran (Supervisor)
    Abstract
    Cancer is an abnormal growth of cells which is one of the major cause of worldwide’s mortality. Circulating Tumor Cells (CTCs) are rare cancer cells released from the primary or metastatic tumors and transported though the peripheral circulatory system and spreads in body and seize healthy organs. Early detection of CTCs can help in overtaking the cancer, hence isolation of CTCs is an essential step for many therapeutics. In spite of its clinical potential, the isolation and detection of CTCs has been a challenging task due to its rare presence amongst other blood cells (as low as 1–10 CTCs per billions of blood cells), similarity to white blood cell in size and also variability in terms of...