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    Cuff-less high-accuracy calibration-free blood pressure estimation using pulse transit time

    , Article Proceedings - IEEE International Symposium on Circuits and Systems, 24 May 2015 through 27 May 2015 ; Volume 2015-July , 2015 , Pages 1006-1009 ; 02714310 (ISSN) ; 9781479983919 (ISBN) Kachuee, M ; Kiani, M.M ; Mohammadzade, H ; Shabany, M ; Sharif University of Technology
    Institute of Electrical and Electronics Engineers Inc  2015
    Abstract
    Recently a few methods have been proposed in the literature for non-invasive cuff-less estimation of systolic and diastolic blood pressures. One of the most prominent methods is to use the Pulse Transit Time (PTT). Although it is proven that PTT has a strong correlation with the systolic and diastolic blood pressures, this relation is highly dependent to each individuals physiological properties. Therefore, it requires per person calibration for accurate and reliable blood pressure estimation from PTT, which is a big drawback. To alleviate this issue, in this paper, a novel method is proposed for accurate and reliable estimation of blood pressure that is calibration-free. This goal is... 

    Cuffless blood pressure estimation algorithms for continuous health-care monitoring

    , Article IEEE Transactions on Biomedical Engineering ; Volume 64, Issue 4 , 2017 , Pages 859-869 ; 00189294 (ISSN) Kachuee, M ; Kiani, M. M ; Mohammadzade, H ; Shabany, M ; Sharif University of Technology
    IEEE Computer Society  2017
    Abstract
    Goal: Continuous blood pressure (BP) monitoring can provide invaluable information about individuals' health conditions. However, BP is conventionally measured using inconvenient cuff-based instruments, which prevents continuous BP monitoring. This paper presents an efficient algorithm, based on the pulse arrival time (PAT), for the continuous and cuffless estimation of the systolic BP, diastolic blood pressure (DBP), and mean arterial pressure (MAP) values. Methods: The proposed framework estimates the BP values through processing vital signals and extracting two types of features, which are based on either physiological parameters or whole-based representation of vital signals. Finally,... 

    Mathematical modeling of heart rate and blood pressure variations due to changes in breathing pattern

    , Article 2013 20th Iranian Conference on Biomedical Engineering, ICBME 2013, Tehran, 18 December 2013 through 20 December 2013 ; 2013 , Pages 54-58 Goldoozian, L. S ; Zahedi, E ; Sharif University of Technology
    IEEE Computer Society  2013
    Abstract
    Analysis of the heart rate (HR) variation due to respiration, known as respiratory sinus arrhythmia (RSA), is a method to assess the autonomic nervous system (ANS) function. In this paper a physiologically-based mathematical model consisting of the cardiorespiratory system and ANS control has been used in order to study the cardiovascular response (mean arterial blood pressure and HR) to breathing with different respiration rates and tidal volumes. Simulation results show that RSA has its maximal amplitude at the respiration frequency of 0.12 Hz and that RSA amplitude varies linearly by tidal volume. These results are in agreement with real data from the literature. In addition, the... 

    Definition and comparison of a new vascular index between young healthy and aged subjects

    , Article IECBES 2014, Conference Proceedings - 2014 IEEE Conference on Biomedical Engineering and Sciences: "Miri, Where Engineering in Medicine and Biology and Humanity Meet", 8 December 2014 through 10 December 2014 ; 2015 , Pages 911-915 ; 9781479940844 (ISBN) Jaafar, R ; Zahedi, E ; Mohd Ali, M. A ; Sharif University of Technology
    Institute of Electrical and Electronics Engineers Inc  2015
    Abstract
    In an effort to identify a useful noninvasive screening tool for cardiovascular diseases (CVD) screening, photoplethysmograph (PPG) signals were acquired and analyzed. These PPG signals were recorded during reactive hyperemia experiments consisting of a 4-minute blood flow blockage of the right arm (RA) brachial artery (BA) using a blood pressure cuff inflator. This procedure is usually done for the assessment of endothelial dysfunction which is a risk factor for developing CVD. In this study, signals of the infrared (IR) and red (R) LED's of the PPG sensor were analyzed. These signals were preprocessed, normalized and slow varying component of the signal (DC values) and the pulsatile... 

    The Capacity of associated subsequence retrieval

    , Article IEEE Transactions on Information Theory ; Volume 67, Issue 2 , 2021 , Pages 790-804 ; 00189448 (ISSN) Tahmasebi, B ; Maddah Ali, M. A ; Motahari, S. A ; Sharif University of Technology
    Institute of Electrical and Electronics Engineers Inc  2021
    Abstract
    The objective of a genome-wide association study (GWAS) is to associate subsequences of individuals' genomes to the observable characteristics called phenotypes (e.g., high blood pressure). Motivated by the GWAS problem, in this paper we introduce the information-theoretic problem of associated subsequence retrieval, where a dataset of N (possibly high-dimensional) sequences of length G, and their corresponding observable (binary) characteristics is given. The sequences are chosen independently and uniformly at random from XG , where X is a finite alphabet. The observable (binary) characteristic is only related to a specific unknown subsequence of length L of the sequences, called associated... 

    Modeling Brachial Blood Pressure by Using Finger PPG Signal

    , M.Sc. Thesis Sharif University of Technology Asadpour, Abdoreza (Author) ; Zahedi, Edmond (Supervisor)
    Abstract
    Nowadays, all of the devices that measure blood pressure commercially at home are using wrist or arm cuffs preventing the systolic or diastolic blood pressure from being measured continuously. Various parameters such as blood flow with some degree of correlation with blood pressure that can be measured noninvasively have been suggested. However, these parameters do not produce accurate estimates for blood pressure. Pulse Transit Time (PTT) which is defined as the interval between the R peak of ECG signal and the next PPG signal valley has shown to have over 90% correlation with systolic blood pressure in past studies. In this thesis, the relationship between the value of the systolic blood... 

    Non-invasive and Continuous Blood Pressure Measurement Using Pulse Transit Time without Cuff Requirement

    , M.Sc. Thesis Sharif University of Technology Esmaili Dastjerdi, Amir Hossein (Author) ; Shabany, Mahdi (Supervisor)
    Abstract
    This thesis addresses cuff-less blood pressure (BP) estimation, for systolic blood pressure (SBP) and diastolic blood pressure (DBP) estimation with the aid of the processing of vital signals. Both with and without calibration per person approaches for BP estimation are considered. A data acquisition hardware is designed for high-resolution sampling of phonocardiogram (PCG), Photoplethysmogram (PPG) and electrocardiogram (ECG). Using these signals, pulse transit time (PTT) and pulse arrival time (PAT) indexes, which would be used for BP estimation with calibration, are extracted. For the BP estimator model using the calibration, A nonlinear model based on PTT or PAT, via modeling the vessels... 

    Design of Efficient Algorithms for Cuff-less and Continuous Estimation of Blood Pressure in Smart Mobile Healthcare Systems

    , M.Sc. Thesis Sharif University of Technology Kachuee, Mohammad (Author) ; Shabany, Mahdi (Supervisor) ; Mohammadzadeh, Hoda (Co-Advisor)
    Abstract
    Continuous Blood Pressure monitoring can provide invaluable information about individuals’ health conditions. However, BP is conventionally measured using inconvenient cuff-based instruments, which prevents continuous BP monitoring. This work presents an efficient algorithm, based on the Pulse Arrival Time (PAT), for the continuous and cuff-less estimation of the Systolic Blood Pressure (SBP), Diastolic Blood Pressure (DBP), and Mean Arterial Pressure (MAP) values. The proposed framework estimates the BP values through processing vital signals and extracting two types of features, which are based on either physiological parameters or whole-based representation of vital signals. Finally, the... 

    2-D Modeling of Blood Flow in Mitral Valve During its Closing and Opening

    , M.Sc. Thesis Sharif University of Technology Jamshidi, Hadi (Author) ; Firoozabadi, Bahar (Supervisor) ; Saeedi, Mohammad Saeed (Co-Supervisor)
    Abstract
    Problems with the mitral valve can make the heart less efficient at pumping blood around the body. Severe problems can lead to heart failure if the valve is not surgically repaired or replaced. A simple approximation of the heart geometry is used and the valve dimensions are based on reported measurements. The primary objective for this study is to design and simulate the opening and closing behavior of the mitral valve using 2D fluid-structure interaction (FSI) model using ADINA software in order to evaluate and investigate the hemodynamic performance and problems of mitral valve, in which the blood is described as a viscous incompressible fluid, and the mitral valve is described as an... 

    Design and Implementation of Non-Invasive Blood Pressure Monitor for Smart Health Application

    , M.Sc. Thesis Sharif University of Technology Amini, Alireza (Author) ; Fakharzadeh Jahromi, Mohammad (Supervisor)
    Abstract
    The blood pressure (BP) is one of the most vital signs to monitor human health. Hypertension is a major public health problem that is associated with morbidity and mortality. In the past decades, the number of people with hypertension disease has been increased. According to Ministry of Health, 54 percent of hypertensive patients are unaware of this health threat. Therefore, accurate and continuous measurement of BP is essential for its prevention and treatment. Traditional non-invasive methods of BP monitoring use an inflatable cuff, which causes discomfort due to occlusion of the artery and can not be used continuously. Numerous studies have attempted to present methods without using a... 

    Robust control of LVAD based on the sub-regional modeling of the heart

    , Article Scientia Iranica ; Volume 23, Issue 6 , 2016 , Pages 2934-2943 ; 10263098 (ISSN) Ravanshadi, S ; Jahed, M ; Sharif University of Technology
    Sharif University of Technology  2016
    Abstract
    Left Ventricular Assist Devices (LVAD) have received renewed interest as a bridge-to-transplantation as well as a bridge-to-recovery device. Ironically, reports of malfunction and complications have hindered the growth of this device. In particular, the main concern is LVAD's susceptibility to excessive backlash and suction as a result of ows that are either too low or high, respectively. This study utilizes a well-established physiological model of the cardiovascular system as a reliable platform to study a proposed adaptive robust controller for a rotary motor based LVAD which overcomes such shortcomings. Proposed controller performance is evaluated by comparing simulated natural heart... 

    Characteristics of early repolarization pattern in the Iranian population

    , Article Iranian Red Crescent Medical Journal ; Volume 19, Issue 3 , 2017 ; 20741804 (ISSN) Mollazadeh, R ; Sehhati, F ; Eslami, M ; Nemati, F ; Monfarednasab, M ; Sefidbakht, S ; Sharif University of Technology
    Kowsar Medical Publishing Company  2017
    Abstract
    Background: The early repolarization pattern (ERP) has been considered a normal variant in electrocardiography (ECG) for a long time. Nevertheless, increasing evidence has demonstrated its association with adverse outcomes. Objectives: The present study aimed to evaluate the prevalence of ERP in the Iranian general population and demonstrate its clinical and ECG correlates. Methods: A cross sectional study, comprising 1424 consecutive healthy adult individuals, was conducted at two university based hospitals in Tehran, Iran in 2012-2013. The ERP prevalence, clinical characteristics and ECG morphology were investigated in volunteers. Results: ERP was present in 136 out of 1,424 people (9.6%).... 

    A portable culture chamber for studying the effects of hydrostatic pressure on cellular monolayers

    , Article Proceedings of the Institution of Mechanical Engineers, Part C: Journal of Mechanical Engineering Science ; 2018 ; 09544062 (ISSN) Kiyoumarsioskouei, A ; Saidi, M ; Mosadegh, B ; Firoozabadi, B ; Sharif University of Technology
    SAGE Publications Ltd  2018
    Abstract
    Hydrostatic pressure is one of the most fundamental and common mechanical stimuli in the body, playing a critical role in the homeostasis of all organ systems. Kidney function is affected by high blood pressure, namely hypertension, by the increased pressure acting on the glomerular capillary walls. This general effect of hypertension is diagnosed as a chronic disease, but underlying mechanistic causes are still not well understood. This paper reports a portable and adaptive device for studying the effects of hydrostatic pressure on a monolayer of cells. The fabricated device fits within a conventional incubation system and microscope. The effects of various pressures and durations were... 

    A portable culture chamber for studying the effects of hydrostatic pressure on cellular monolayers

    , Article Proceedings of the Institution of Mechanical Engineers, Part C: Journal of Mechanical Engineering Science ; Volume 233, Issue 3 , 2019 , Pages 807-816 ; 09544062 (ISSN) Kiyoumarsioskouei, A ; Saidi, M. S ; Mosadegh, B ; Firoozabadi, B ; Sharif University of Technology
    SAGE Publications Ltd  2019
    Abstract
    Hydrostatic pressure is one of the most fundamental and common mechanical stimuli in the body, playing a critical role in the homeostasis of all organ systems. Kidney function is affected by high blood pressure, namely hypertension, by the increased pressure acting on the glomerular capillary walls. This general effect of hypertension is diagnosed as a chronic disease, but underlying mechanistic causes are still not well understood. This paper reports a portable and adaptive device for studying the effects of hydrostatic pressure on a monolayer of cells. The fabricated device fits within a conventional incubation system and microscope. The effects of various pressures and durations were... 

    Blood pressure estimation using photoplethysmogram signal and its morphological features

    , Article IEEE Sensors Journal ; Volume 20, Issue 8 , 2020 , Pages 4300-4310 Hasanzadeh, N ; Ahmadi, M. M ; Mohammadzade, H ; Sharif University of Technology
    Institute of Electrical and Electronics Engineers Inc  2020
    Abstract
    In this paper, we present a machine learning model to estimate the blood pressure (BP) of a person using only his photoplethysmogram (PPG) signal. We propose algorithms to better detect some critical points of the PPG signal, such as systolic and diastolic peaks, dicrotic notch and inflection point. These algorithms are applicable to different PPG signal morphologies and improve the precision of feature extraction. We show that the logarithm of dicrotic notch reflection index, the ratio of low-to high-frequency components of heart rate (HR) variability signal, and the product of HR multiplied by the modified Normalized Pulse Volume (mNPV) are the key features in accurately estimating the BP... 

    Blood Pressure Measurement by using Pulse Transit Time

    , M.Sc. Thesis Sharif University of Technology Mazaheri, Samaneh (Author) ; Zahedi, Edmond (Supervisor) ; Jahed, Mehran (Supervisor)
    Abstract
    Continuous and non-invasive blood pressure (BP) measurement systems generally utilize applanation tonometry and vascular unloading. Some of them satisfies the AAMI standards (|mean|<5, |SD|<8). Unfortunately they are hardly to be widely affordable due to the complicated mechanical structure and high production cost. Till now those devices are seldom being used in operation room and generally used in clinical researches. In 2000, a linear model using pulse transit time (PTT) to continuous and non-invasive blood pressure (BP) measurement was proposed. Due to the nonlinear performance parameters of the arteries, researchers have used nonlinear models to promote this method. Although the... 

    Validation of the Saadat NIBP module according to the ANSI/AAMI-SP10 protocol

    , Article 2013 20th Iranian Conference on Biomedical Engineering, ICBME 2013 ; Deembec , 2013 , Pages 199-202 Sadaghiani, M ; Mashayekhi, G ; Behzadfar, N ; Yaghoobzadeh, A ; Babaee, T ; Sharif University of Technology
    IEEE Computer Society  2013
    Abstract
    This study is conducted with the aim of validating the Saadat non-invasive blood pressure (NIBP) module accuracy and reliability against direct intra arterial pressure measurement (IBP) according to the ANSI/AAMI SP10-2002 guidelines. Measurement and comparison procedure were done in a static population of 19 adult patients with brachial catheterized arterial line with total measurements of 195 under supervision of a highly experienced cardiovascular anesthesiologist in accordance with the ANSI/AAMI SP10-2002 regulation. Data analysis was performed based on the protocol criteria. In order to represent relationships between the test device and the reference method, Bland-Altman graphical... 

    Single-replicate longitudinal data analysis in the presence of multiple instrumental measurement errors

    , Article Computers and Industrial Engineering ; Volume 141 , 2020 Moazeni, M ; Behbahani, M ; Khedmati, M ; Akhavan Niaki, S. T ; Sharif University of Technology
    Elsevier Ltd  2020
    Abstract
    In this paper, a novel method as a combination of the expectation–maximization (EM) algorithm and Variogram is proposed to decompose the longitudinal measurement errors in the absence of replications and the presence of multiple instrumental measurement errors. In the proposed method, multiple measurements are considered where the units are observed by several distinct instruments (gauges). The approach decouples the observed variance of the measurement model into the process and measurement system variances. In addition, it decomposes the variance of multiple instruments into the process and instrument variances. In the end, the proposed model is validated and tested based on simulated... 

    A combined dynamical sequential network for generating coupled cardiovascular signals with different beat types

    , Article ; 2010 3rd International Symposium on Applied Sciences in Biomedical and Communication Technologies, ISABEL 2010, 7 November 2010 through 10 November 2010 , 2010 ; 9781424481323 (ISBN) Sayadi, O ; Shamsollahi, M. B ; Sharif University of Technology
    Abstract
    We present generalizations of the previously published artificial models for generating abnormal cardiac rhythms to provide simulations of coupled cardiovascular (CV) signals with different beat morphologies. Using a joint dynamical formulation, we generate the normal morphologies of the cardiac cycle using a sum of Gaussian kernels, fitted to real CV recordings. The joint inter-dependencies of CV signals are introduced by assuming the same angular frequency and a phase coupling. Abnormal beats are then specified as new dynamical trajectories. An ergadic first-order Markov chain is also used for switching between normal and abnormal beat types. Probability transitions can be learned from... 

    Non-invasive blood pressure estimation using phonocardiogram

    , Article Proceedings - IEEE International Symposium on Circuits and Systems, 28 May 2017 through 31 May 2017 ; 2017 ; 02714310 (ISSN) ; 9781467368520 (ISBN) Esmaili Dastjerdi, A ; Kachuee, M ; Shabany, M ; Sharif University of Technology
    Abstract
    This paper presents a novel approach based on pulse transit time (PTT) for the estimation of blood pressure (BP). In order to achieve this goal, a data acquisition hardware is designed for high-resolution sampling of phonocardiogram (PCG) and photoplethysmogram (PPG). These two signals can derive PTT values. Meanwhile, a force-sensing resistor (FSR) is placed under the cuff of the BP reference device to mark the moments of measurements accurately via recording instantaneous cuff pressure. For deriving the PTT-BP models, a calibration procedure including a supervised physical exercise is conducted for each individual. The proposed method is evaluated on 24 subjects. The final results prove...