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    Some investigations on the ability of an indigenous thiobacillus ferrooxidans, used in Bio-SR process

    , Article CHISA 2006 - 17th International Congress of Chemical and Process Engineering, Prague, 27 August 2006 through 31 August 2006 ; 2006 ; 8086059456 (ISBN); 9788086059457 (ISBN) SYaghmaei ; Salimi, F ; Mousavi, S. M ; Sharif University of Technology
    The physicochemical techniques presently available for treatment of H2S containing gases are many and varied. In near future small gas reservoirs with high concentration of H2S will be explored, therefore the gas processing industry is seeking novel, cost effective, environmentally compatible and operator friendly technologies applicable to the small volume producrs. The continuing search for more economical methods has led to investigations into microbiological processes. The biological process which has been studied in this research is Bio-SR process. Bio-SR process uses thiobacillus ferroxidans bacteria to regenerate gas treating solution (ferrous sulfate). In this way, the effects of... 

    A molecular dynamics simulation study of nanomechanical properties of asymmetric lipid bilayer

    , Article Journal of Membrane Biology ; Volume 246, Issue 1 , 2013 , Pages 67-73 ; 00222631 (ISSN) Maftouni, N ; Amininasab, M ; Vali, M ; Ejtehadi, M ; Kowsari, F ; Sharif University of Technology
    A very important part of the living cells of biological systems is the lipid membrane. The mechanical properties of this membrane play an important role in biophysical studies. Investigation as to how the insertion of additional phospholipids in one leaflet of a bilayer affects the physical properties of the obtained asymmetric lipid membrane is of recent practical interest. In this work a coarse-grained molecular dynamics simulation was carried out in order to compute the pressure tensor, the lateral pressure, the surface tension and the first moment of lateral pressure in each leaflet of such a bilayer. Our simulations indicate that adding more phospholipids into one monolayer results in... 

    Design and physicochemical characterization of lysozyme loaded niosomal formulations as a new controlled delivery system

    , Article Pharmaceutical Chemistry Journal ; Volume 53, Issue 10 , 2020 , Pages 921-930 Sadeghi, S ; Ehsani, P ; Cohan, R. A ; Sardari, S ; Akbarzadeh, I ; Bakhshandeh, H ; Norouzian, D ; Sharif University of Technology
    Springer  2020
    Lysozyme loaded niosomes containing various molar ratios of two kinds of surfactants were prepared and the properties of these niosomal formulations were studied. The results revealed that the size of niosomes varied between 240.06 ± 32.41 and 895.2 ± 20.84 nm. Formulations with the lowest size and no precipitation had entrapment efficiencies ranging from 60.644 ± 3.310 to 66.333 ± 1.98%. Their controlled release profiles after 48 h were 15.67, 20.67 and 31.50%. After 2 months, the most stable formulation in terms of size, PDI, zeta potential, and entrapment efficiency was used to study the secondary structures of lysozyme in niosomal and free forms. Lysozyme loaded niosome and lysozyme... 

    Nanomedicine applications in orthopedic medicine: State of the art

    , Article International Journal of Nanomedicine ; Volume 10 , 2015 , Pages 6039-6054 ; 11769114 (ISSN) Mazaheri, M ; Eslahi, N ; Ordikhani, F ; Tamjid, E ; Simchi, A ; Sharif University of Technology
    Dove Medical Press Ltd  2015
    The technological and clinical need for orthopedic replacement materials has led to significant advances in the field of nanomedicine, which embraces the breadth of nanotechnology from pharmacological agents and surface modification through to regulation and toxicology. A variety of nanostructures with unique chemical, physical, and biological properties have been engineered to improve the functionality and reliability of implantable medical devices. However, mimicking living bone tissue is still a challenge. The scope of this review is to highlight the most recent accomplishments and trends in designing nanomaterials and their applications in orthopedics with an outline on future directions... 

    Microfluidic systems for stem cell-based neural tissue engineering

    , Article Lab on a Chip - Miniaturisation for Chemistry and Biology ; Volume 16, Issue 14 , 2016 , Pages 2551-2571 ; 14730197 (ISSN) Karimi, M ; Bahrami, S ; Mirshekari, H ; Moosavi Basri, S. M ; Bakhshian Nik, A ; Aref, A. R ; Akbari, M ; Hamblin, M. R ; Sharif University of Technology
    Royal Society of Chemistry  2016
    Neural tissue engineering aims at developing novel approaches for the treatment of diseases of the nervous system, by providing a permissive environment for the growth and differentiation of neural cells. Three-dimensional (3D) cell culture systems provide a closer biomimetic environment, and promote better cell differentiation and improved cell function, than could be achieved by conventional two-dimensional (2D) culture systems. With the recent advances in the discovery and introduction of different types of stem cells for tissue engineering, microfluidic platforms have provided an improved microenvironment for the 3D-culture of stem cells. Microfluidic systems can provide more precise... 

    Development of kinetic model for CO hydrogenation reaction over supported Fe-Co-Mn catalyst

    , Article New Journal of Chemistry ; Volume 41, Issue 18 , 2017 , Pages 10452-10466 ; 11440546 (ISSN) Arsalanfar, M ; Abdouss, M ; Mirzaei, N ; Zamani, Y ; Sharif University of Technology
    Royal Society of Chemistry  2017
    Kinetic modeling of CO hydrogenation over Fe-Co-Mn catalyst was investigated; a ternary catalyst was prepared using incipient wetness impregnation. The kinetic parameters were determined from experiments carried out in a fixed bed micro-reactor under the following process conditions: T = 523.15-533.15 K, P = 1-10 bar, H2/CO = 1/1-3/1 and space velocity = 4500 h-1. Seventeen rate expressions were derived from five different mechanisms according to Langmuir-Hinshelwood-Hougen-Watson (LHHW) and Eley-Rideal (ER) mechanisms and were tested against the experimental data. Non-linear regression method was used to estimate different kinetic parameters; according to the obtained experimental results... 

    Molecular simulation of protein dynamics in nanopores. I. Stability and folding

    , Article Journal of Chemical Physics ; Volume 128, Issue 11 , 2008 ; 00219606 (ISSN) Javidpour, L ; Rahimi Tabar, M. R ; Sahimi, M ; Sharif University of Technology
    Discontinuous molecular dynamics simulations, together with the protein intermediate resolution model, an intermediate-resolution model of proteins, are used to carry out several microsecond-long simulations and study folding transition and stability of α -de novo-designed proteins in slit nanopores. Both attractive and repulsive interaction potentials between the proteins and the pore walls are considered. Near the folding temperature Tf and in the presence of the attractive potential, the proteins undergo a repeating sequence of folding/partially folding/unfolding transitions, with Tf decreasing with decreasing pore sizes. The unfolded states may even be completely adsorbed on the pore's... 

    Larval habitats and biodiversity of anopheline mosquitoes (Diptera: Culicidae) in a malarious area of southern Iran

    , Article Journal of Vector Borne Diseases ; Volume 49, Issue 2 , Jun , 2012 , Pages 91-100 ; 09729062 (ISSN) Hanafi-Bojd, A. A ; Vatandoost, H ; Oshaghi, M. A ; Charrahy, Z ; Haghdoost, A. A ; Sedaghat, M. M ; Abedi, F ; Soltani, M ; Raeisi, A ; Sharif University of Technology
    JVBD  2012
    Background & objectives: Malaria is the most important mosquito-borne disease in Iran. It is endemic in south to southeastern part of the country. Knowledge about bio-ecology of vectors will support authorities for appropriate management of the disease. Bashagard district is one of the main endemic areas for malaria in south of Iran. This study was conducted to determine anopheline fauna, diversity and affinity in the area, characterization of larval habitats, and mapping their potential distribution across the district. Methods: The potential aquatic habitats for Anopheles larvae were extracted from Indian Remote Sensing Satellite (IRS) image and digital elevation model of the area using... 

    Synthesis, properties and biomedical applications of carbon-based quantum dots: an updated review

    , Article Biomedicine and Pharmacotherapy ; Volume 87 , 2017 , Pages 209-222 ; 07533322 (ISSN) Namdari, P ; Negahdari, B ; Eatemadi, A ; Sharif University of Technology
    Elsevier Masson SAS  2017
    Carbon-based quantum dots (CQDs) are a newly developed class of carbon nano-materials that have attracted much interest and attention as promising competitors to already available semiconductor quantum dots owing to their un-comparable and unique properties. In addition, controllability of CQDs unique physiochemical properties is as a result of their surface passivation and functionalization. This is an update article (between 2013 and 2016) on the recent progress, characteristics and synthesis methods of CQDs and different advantages in varieties of applications. © 2017 Elsevier Masson SAS  

    کلیدواژه های تکراریCurcumin loading potentiates the neuroprotective efficacy of Fe3O4 magnetic nanoparticles in cerebellum cells of schizophrenic rats

    , Article Biomedicine and Pharmacotherapy ; Volume 108 , 2018 , Pages 1244-1252 ; 07533322 (ISSN) Naserzadeh, P ; Ashrafi Hafez, A ; Abdorahim, M ; Abdollahifar, M. A ; Shabani, R ; Peirovi, H ; Simchi, A ; Ashtari, K ; Sharif University of Technology
    Background: The aim of this study was to investigate the neurotoxic effects of Fe3O4 magnetic- CurNPs on isolated schizophrenia mitochondria of rats as an in vivo model. Methods: We designed CMN loaded superparamagnetic iron oxide nanoparticles (SPIONs) (Fe3O4 magnetic- CurNPs) to achieve an enhanced therapeutic effect. The physicochemical properties of Fe3O4 magnetic- CurNPs were characterized using X-ray diffraction (XRD), and dynamic laser light scattering (DLS) and zeta potential. Further, to prove Fe3O4 magnetic- CurNPs results in superior therapeutic effects, and also, the mitochondrial membrane potential collapse, mitochondrial complex II activity, reactive oxygen species generation,... 

    Pyromellitic dianhydride crosslinked cyclodextrin nanosponges for curcumin controlled release; formulation, physicochemical characterization and cytotoxicity investigations

    , Article Journal of Microencapsulation ; Volume 36, Issue 8 , 2019 , Pages 715-727 ; 02652048 (ISSN) Rafati, N ; Zarrabi, A ; Caldera, F ; Trotta, F ; Ghias, N ; Sharif University of Technology
    Taylor and Francis Ltd  2019
    Aim: In this study, a nanosponge structure was synthesised with capability of encapsulating curcumin as a model polyphenolic compound and one of the herbal remedies that have widely been considered due to its ability to treat cancer. Methods: FTIR, DSC and XRD techniques were performed to confirm the formation of the inclusion complex of the nanosponge-drug. Results: DSC and XRD patterns showed an increasing stability and a decreasing crystallinity of curcumin after formation of inclusion complex. Encapsulation efficiency was 98% (w/w) and a significant increase was observed in loading capacity (184% w/w). The results of cytotoxicity assessments demonstrated no cell toxicity on the healthy... 

    Application of nano-structured materials in anaerobic digestion: Current status and perspectives

    , Article Chemosphere ; Volume 229 , 2019 , Pages 188-199 ; 00456535 (ISSN) Baniamerian, H ; Ghofrani Isfahani, P ; Tsapekos, P ; Alvarado Morales, M ; Shahrokhi, M ; Vossoughi, M ; Angelidaki, I ; Sharif University of Technology
    Elsevier Ltd  2019
    Nanotechnology is gaining more attention in biotechnological applications as a research area with a huge potential. Nanoparticles (NPs)can influence the rate of anaerobic digestion (AD)as the nano-sized structures, with specific physicochemical properties, interact with substrate and microorganisms. The present work has classified the various types of additives used to improve the AD processes. Nanomaterials as new additives in AD process are classified into four categories: Zero-valent metallic NPs, Metal oxide NPs, Carbon based nanomaterials, and Multi-compound NPs. In the following, application of nanomaterials in AD process is reviewed and negative and positive effects of these materials... 

    Double network hydrogel of sodium alginate/polyacrylamide cross-linked with POSS: Swelling, dye removal and mechanical properties

    , Article International Journal of Biological Macromolecules ; Volume 129 , 2019 , Pages 187-197 ; 01418130 (ISSN) Bahrami, Z ; Akbari, A ; Eftekhari Sis, B ; Sharif University of Technology
    Elsevier B.V  2019
    In this work, for the first time, we presented a novel design strategy to fabricate a new type of Octa-aminopropyl polyhedral oligomeric silsesquioxane hydrochloride salt (OA-POSS)-based Alg/PAAm DN gels, consisting of PAAm gel as the first chemical network and Alg/OA-POSS gel as the second chemical-physical network. Incorporation of OA-POSS nanoparticles with various feed ratio into the second network not only led to form strong coordination interactions but also in comparison to the other Alg/PAAm gels demonstrated superior mechanical properties. pH, temperature, contact time and salt effects parameters were studied on the swelling and dye removal properties of the synthesized DN hybrid... 

    AntAngioCOOL: computational detection of anti-angiogenic peptides

    , Article Journal of Translational Medicine ; Volume 17, Issue 1 , 2019 ; 14795876 (ISSN) Zahiri, J ; Khorsand, B ; Yousefi, A. A ; Kargar, M. J ; Shirali Hossein Zade, R ; Mahdevar, G ; Sharif University of Technology
    BioMed Central Ltd  2019
    Background: Angiogenesis inhibition research is a cutting edge area in angiogenesis-dependent disease therapy, especially in cancer therapy. Recently, studies on anti-angiogenic peptides have provided promising results in the field of cancer treatment. Methods: A non-redundant dataset of 135 anti-angiogenic peptides (positive instances) and 135 non anti-angiogenic peptides (negative instances) was used in this study. Also, 20% of each class were selected to construct an independent test dataset (see Additional files 1, 2). We proposed an effective machine learning based R package (AntAngioCOOL) to predict anti-angiogenic peptides. We have examined more than 200 different classifiers to build... 

    Current scenario of the tehran municipal solid waste handling rules towards green technology

    , Article International Journal of Environmental Research and Public Health ; Volume 16, Issue 6 , 2019 ; 16617827 (ISSN) Rupani, P. F ; Maleki Delarestaghi, R ; Asadi, H ; Rezania, S ; Park, J ; Abbaspour, M ; Shao, W ; Sharif University of Technology
    MDPI AG  2019
    This study aims to study the waste management process and recycling of municipal waste in Tehran. Currently, Kahrizak is the defined landfill area which collects the waste generated from 22 districts of Tehran. The organic wastes undergo to the windrow composting method in order to manage the partial of the waste generated in the city. Samples from the compost pile generated in Kahrizak were examined to evaluate its fertilizer value to be used further by the farmers. The results show that the obtained compost does not reach the acceptable quality to be used further in agriculture, due to lack of homogeneity, aeration and presence of heavy metals. Overall, it has been concluded that, due to... 

    Effect of physico-chemical properties of nanoparticles on their intracellular uptake

    , Article International Journal of Molecular Sciences ; Volume 21, Issue 21 , 2020 , Pages 1-20 Sabourian, P ; Yazdani, G ; Ashraf, S. S ; Frounchi, M ; Mashayekhan, S ; Kiani, S ; Kakkar, A ; Sharif University of Technology
    MDPI AG  2020
    Cellular internalization of inorganic, lipidic and polymeric nanoparticles is of great significance in the quest to develop effective formulations for the treatment of high morbidity rate diseases. Understanding nanoparticle–cell interactions plays a key role in therapeutic interventions, and it continues to be a topic of great interest to both chemists and biologists. The mechanistic evaluation of cellular uptake is quite complex and is continuously being aided by the design of nanocarriers with desired physico-chemical properties. The progress in biomedicine, including enhancing the rate of uptake by the cells, is being made through the development of structure–property relationships in... 

    QSAR study of heparanase inhibitors activity using artificial neural networks and Levenberg-Marquardt algorithm

    , Article European Journal of Medicinal Chemistry ; Volume 43, Issue 3 , 2008 , Pages 548-556 ; 02235234 (ISSN) Jalali Heravi, M ; Asadollahi Baboli, M ; Shahbazikhah, P ; Sharif University of Technology
    A linear and non-linear quantitative structure-activity relationship (QSAR) study is presented for modeling and predicting heparanase inhibitors' activity. A data set that consisted of 92 derivatives of 2,3-dihydro-1,3-dioxo-1H-isoindole-5-carboxylic acid, furanyl-1,3-thiazol-2-yl and benzoxazol-5-yl acetic acids is used in this study. Among a large number of descriptors, four parameters classified as physico-chemical, topological and electronic indices are chosen using stepwise multiple regression technique. The artificial neural networks (ANNs) model shows superiority over the multiple linear regressions (MLR) by accounting 87.9% of the variances of antiviral potency of the heparanase... 

    Photoluminescent carbon quantum dot/poly-L-Lysine core-shell nanoparticles: A novel candidate for gene delivery

    , Article Journal of Drug Delivery Science and Technology ; Volume 61 , 2021 ; 17732247 (ISSN) Hasanzadeh, A ; Mofazzal Jahromi, M. A ; Abdoli, A ; Mohammad Beigi, H ; Fatahi, Y ; Nourizadeh, H ; Zare, H ; Kiani, J ; Radmanesh, F ; Rabiee, N ; Jahani, M ; Mombeiny, R ; Karimi, M ; Sharif University of Technology
    Editions de Sante  2021
    Cationic polymers such as poly-L-lysine (PLL) are able to interact electrostatically with DNA to produce polymeric systems with nanometric diameters due to the neutralization and accumulation of DNA. This study integrates the outstanding properties of carbon quantum dots (CQDs) with PLL to develop a novel gene delivery vehicle with a core-shell hybrid nanostructure. The CQD/PLL core-shell nanoparticles (NPs) were, therefore, synthesized in such a way that they had narrow size distribution and an average diameter under 10 nm, both of which were confirmed by dynamic light scattering (DLS) and transmission electron microscopy (TEM). Fourier transform infrared (FTIR) spectroscopy exhibited that... 

    On the optimality of the genetic code, with the consideration of coevolution theory by comparison of prominent cost measure matrices

    , Article Journal of Theoretical Biology ; Volume 235, Issue 3 , 2005 , Pages 318-325 ; 00225193 (ISSN) Goodarzi, H ; Shateri Najafabadi, H ; Hassani, K ; Ahmadi Nejad, H ; Torabi, N ; Sharif University of Technology
    Statistical and biochemical studies have revealed non-random patterns in codon assignments. The canonical genetic code is known to be highly efficient in minimizing the effects of mistranslation errors and point mutations, since it is known that when an amino acid is converted to another due to error, the biochemical properties of the resulted amino acid are usually very similar to those of the original one. In this study, using altered forms of the fitness functions used in the prior studies, we have optimized the parameters involved in the calculation of the error minimizing property of the genetic code so that the genetic code outscores the random codes as much as possible. This work also... 

    Effect of gamma ray on poly(lactic acid)/poly(vinyl acetate-co-vinyl alcohol) blends as biodegradable food packaging films

    , Article Radiation Physics and Chemistry ; Vol. 96 , 2014 , pp. 12-18 ; ISSN: 0969806X Razavi, S. M ; Dadbin, S ; Frounchi, M ; Sharif University of Technology
    Poly(lactic acid) (PLA)/poly(vinyl acetate-. co-vinyl alcohol) [P(VAc-. co-VA)] blends as new transparent film packaging materials were prepared at various blend compositions and different vinyl alcohol contents. The blends and pure PLA were irradiated by gamma rays to investigate the extent of changes in the packaging material during gamma ray sterilization process. The miscibility of the blends was dependent on the blend composition and vinyl alcohol content; gamma irradiation had little effect on the extent of miscibility. The glass transition temperature of pure PLA and PLA/P(VAc-. co-VA) miscible blends reduced after irradiation. On the other hand in PLA/P(VAc-. co-VA) immiscible...