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    Efficient wound healing by antibacterial property: Advances and trends of hydrogels, hydrogel-metal NP composites and photothermal therapy platforms

    , Article Journal of Drug Delivery Science and Technology ; Volume 73 , 2022 ; 17732247 (ISSN) Ahmadian, Z ; Gheybi, H ; Adeli, M ; Sharif University of Technology
    Editions de Sante  2022
    Abstract
    Bacterial infection is one of the biggest challenges in wound healing and imposes enormous burden on patient and medical system. Moreover, multidrug resistant microorganisms (MDR) limit the usage of therapeutic agents including antibiotics for wound treatment. Hydrogels are three-dimensional networks that have emerged as efficient scaffolds for the treatment of infected wounds. In addition to their intrinsic antibacterial activities, hydrogels are able to load and release therapeutic agents to keep the efficient dose during wound healing process. At the same lines, incorporation of metal nanoparticles (NPs) into hydrogels boosts their antibacterial activity. Moreover, photothermal agents... 

    Mathematical modeling of dermal wound healing: A numerical solution

    , Article 2010 The 2nd International Conference on Computer and Automation Engineering, ICCAE 2010, 26 February 2010 through 28 February 2010, Singapore ; Volume 2 , 2010 , Pages 153-156 ; 9781424455850 (ISBN) Azizi, A ; Ghaemi Osgouie, K ; Sharif University of Technology
    2010
    Abstract
    Though wound healing process is well-researched, this area is poorly known. One reason is that all interactions have not been discovered, the main reason, though, is that the involved processes interact in a very complicated manner with nonlinear feedback. Such complex feedback mechanisms can be easily addressed by mathematical modeling. This paper contains a review of the mathematical modeling of cell interaction with extracellular matrix components during the process of dermal wound healing with focusing on remodeling phase. The models are of partial differential equation type and solved by numerical method  

    Dermal wound healing-remodeling phase: A biological review

    , Article 2010 The 2nd International Conference on Computer and Automation Engineering, ICCAE 2010, 26 February 2010 through 28 February 2010, Singapore ; Volume 2 , 2010 , Pages 88-90 ; 9781424455850 (ISBN) Azizi, A ; Ghaemi Osgouie, K ; Sharif University of Technology
    2010
    Abstract
    Though wound healing process is well-researched, this area is poorly known. One reason is that all interactions have not been discovered, the main reason, though, is that the involved processes interact in a very complicated manner with nonlinear feedback. Such complex feedback mechanisms can be easily addressed by mathematical modeling. This paper contains a review of the mathematical modeling of cell interaction with extracellular matrix components during the process of dermal wound healing with focusing on remodeling phase. The models are of partial differential equation type and solved by finite element method  

    Modeling of dermal wound healing-remodeling phase by neural networks

    , Article 2009 International Association of Computer Science and Information Technology - Spring Conference, IACSIT-SC 2009, Singapore, 17 April 2009 through 20 April 2009 ; 2009 , Pages 447-450 ; 9780769536538 (ISBN) Azizi, A ; Seifipour, N ; Sharif University of Technology
    2009
    Abstract
    Wound healing is a complex biological process dependent on multiple variables: tissue oxygenation, wound size, contamination, etc. Many of these factors depend on multiple factors themselves. Mechanisms for some interactions between these factors are still unknown, presenting a barrier for scientists intending to model wound healing using an object-based programming approach. In this paper we focus on the neural networks and regard them as function approximators, and attempt to simulate remodeling phase of dermal wound healing process using neural networks as an intelligence technique. © 2009 IEEE  

    Fabrication of Artificial skin with Electrospun of Nanofiber made of PCL and PVA

    , M.Sc. Thesis Sharif University of Technology Mohseni, Mina (Author) ; Shamloo, Amir (Supervisor) ; Naghdabadi, Reza (Co-Advisor) ; Vosooghi, Manoochehr (Co-Advisor) ; Firoozbakhsh, Keikhosro (Co-Advisor)
    Abstract
    The main goal of this project is to fabricate the scaffolds including Polycaprolactone and Polyvinyle alcohol nanofibers in order to use as artificial skin. For this purpose, electrospinning parameters have been optimized for various injection rates and the scaffolds containing different percent of PCL and PVA have been made. By investigating the cell growth on these scaffolds, the one made up PVA/PCL (30% ) has been introduced as the best scaffold. To improve biological properties of chosen scaffold, a layer of collagen was coated. The angiogenesis capacity has been improved by adding Heparin to PVA nanofibers. Based on assay of heparin release, it was shown that Heparin is released within... 

    Construction of Scaffold by Electrospinning Method for Use in Skin Tissue Engineering

    , M.Sc. Thesis Sharif University of Technology Heidari Forushani, Parisa (Author) ; Alemzadeh, Iran (Supervisor) ; Vosoughi, Manouchehr (Supervisor)
    Abstract
    Making artificial skin and skin alternatives is one of the most important areas in tissue engineering. Although much progress has been made so far, there is still no definitive cure for second- and third-degree burns. To create new tissue in the body, a suitable substrate for cells is needed, which is called scaffolding, and an ideal scaffold in tissue engineering should mimic the dimensions of extracellular matrix, and nanofibers seem to be the best option for this purpose. Among the methods of manufacturing of nanofibers, electrospun is very easy and accurate method. In previous studies, many natural and synthetic polymers such as chitosan, alginate, collagen, polyathylene oxide, etc.... 

    Modeling of forced dermal wound healing using intelligent techniques

    , Article 2010 The 2nd International Conference on Computer and Automation Engineering, ICCAE 2010, 26 February 2010 through 28 February 2010, Singapore ; Volume 2 , 2010 , Pages 207-211 ; 9781424455850 (ISBN) Azizi, A ; Ghaemi Osgouie, K ; Sharif University of Technology
    2010
    Abstract
    Wound healing is a complex biological process dependent on multiple variables: tissue oxygenation, wound size, contamination, etc. Many of these factors depend on multiple factors themselves. Mechanisms for some interactions between these factors are still unknown but it is generally accepted that collagen synthesis, accumulation and organization are increased by mechanical stimuli, resulting in a forced healing process which improves mechanical properties of the damaged tissue. In this paper we focus on the neural networks and regard them as function approximators, and attempt to simulate remodeling phase of dermal wound healing process using neural networks as an intelligent technique  

    Mathematical modeling of dermal wound healing's remodeling phase: a finite element solution

    , Article 2009 International Association of Computer Science and Information Technology - Spring Conference, IACSIT-SC 2009, Singapore, 17 April 2009 through 20 April 2009 ; 2009 , Pages 529-532 ; 9780769536538 (ISBN) Azizi, A ; Seifipour, N ; Sharif University of Technology
    2009
    Abstract
    Though wound healing process is well-researched, this area is poorly known. One reason is that all interactions have not been discovered, the main reason, though, is that the involved processes interact in a very complicated manner with nonlinear feedback. Such complex feedback mechanisms can be easily addressed by mathematical modeling. This paper contains a review of the mathematical modeling of cell interaction with extracellular matrix components during the process of dermal wound healing with focusing on remodeling phase. The models are of partial differential equation type and solved by finite element method. © 2009 IEEE  

    Freeze-gelled alginate/gelatin scaffolds for wound healing applications: An in vitro, in vivo study

    , Article Materials Science and Engineering C ; Volume 113 , 2020 Afjoul, H ; Shamloo, A ; Kamali, A ; Sharif University of Technology
    Elsevier Ltd  2020
    Abstract
    In this study, fabrication of a three-dimensional porous scaffold was performed using freeze gelation method. Recently, fabrication of scaffolds using polymer blends has become common for many tissue engineering applications due to their unique tunable properties. In this work, we fabricated alginate-gelatin porous hydrogels for wound healing application using a new method based on some modifications to the freeze-gelation method. Alginate and gelatin were mixed in three different ratios and the resulting solutions underwent freeze gelation to obtain 3D porous matrices. We analyzed the samples using different characterization tests. The scanning electron microscopy (SEM) results indicated... 

    Fabrication of a Multi-Layered Scaffold to Be Used in Dermal Wound Healing

    , M.Sc. Thesis Sharif University of Technology Kamali, Ali (Author) ; Shamloo, Amir (Supervisor) ; Asghari, Mohsen (Co-Advisor)
    Abstract
    Wound healing by engineered scaffolds is a new step in bio-technology and medical studies in recent years. The goal of the current study is to propose a novel structure for a tissue-engineered scaffold to be used in wound healing. Influenced from the multi-layered structure of natural human skin, the fabricated scaffold consists of two layers to maximize similarity with natural skin. This product is comprised of an electrospun layer made of polycaprolactone and polyvinyl alcohol and a hydrogel layer made of chitosan and gelatin. In order to form a porous medium in the hydrogel layer, freeze-gelation was used instead of freeze drying. The evaluation of fabricated scaffolds was performed by... 

    Modeling and Control of Dermal Wound Healing-Remodeling Phase by Computational Intelligent Techniqes

    , M.Sc. Thesis Sharif University of Technology Azizi, Aydin (Author) ; Seifipour, Navid (Supervisor)
    Abstract
    Wound healing is a complex biological process dependent on multiple variables: tissue oxygenation, wound size, contamination, etc. Many of these factors depend on multiple factors themselves. Mechanisms for some interactions between these factors are still unknown. In this resarch we try to simulate and control wound healing process with focusing on remodeling phase by neural networks as an intelligence technique. For these purposes some materials like mathematical modeling, finite elements method, and effect of external forces on the scar tissue are used here  

    Synergistic Wound Healing by Novel Ag@ZIF-8 Nanostructures

    , Article International Journal of Pharmaceutics ; Volume 629 , 2022 ; 03785173 (ISSN) Barjasteh, M ; Mohsen Dehnavi, S ; Ahmadi Seyedkhani, S ; Yahya Rahnamaee, S ; Golizadeh, M ; Sharif University of Technology
    Elsevier B.V  2022
    Abstract
    In this paper, novel zeolitic imidazolate framework-8 (ZIF-8) functionalized with Ag (Ag@ZIF-8) nanoparticles were synthesized through a green, facile and environmental-friendly process for wound dressing applications. X-ray diffraction revealed that the ZIF-8 and Ag@ZIF-8 were successfully synthesized by green solvents at ambient temperature. Field-emission scanning electron microscopy indicated a homogeneous porous blend of ∼30 nm chitosan/bacterial cellulose (CS/BC) nanofibers embedded with ∼80–110 nm nanoparticles of the ZIF-8 and Ag@ZIF-8. Transmission electron microscopy revealed the Ag@ZIF-8 nanostructures consist of ZIF-8 cores that are covered by 5–20 nm Ag nanoparticles. MTT assay... 

    Drug delivery systems and materials for wound healing applications

    , Article Advanced Drug Delivery Reviews ; Volume 127 , 2018 , Pages 138-166 ; 0169409X (ISSN) Saghazadeh, S ; Rinoldi, C ; Schot, M ; Saheb Kashaf, S ; Sharifi, F ; Jalilian, E ; Nuutila, K ; Giatsidis, G ; Mostafalu, P ; Derakhshandeh, H ; Yue, K ; Swieszkowski, W ; Memic, A ; Tamayol, A ; Khademhosseini, A ; Sharif University of Technology
    Elsevier B.V  2018
    Abstract
    Chronic, non-healing wounds place a significant burden on patients and healthcare systems, resulting in impaired mobility, limb amputation, or even death. Chronic wounds result from a disruption in the highly orchestrated cascade of events involved in wound closure. Significant advances in our understanding of the pathophysiology of chronic wounds have resulted in the development of drugs designed to target different aspects of the impaired processes. However, the hostility of the wound environment rich in degradative enzymes and its elevated pH, combined with differences in the time scales of different physiological processes involved in tissue regeneration require the use of effective drug... 

    Synthesis of nanobentonite–poly(vinyl alcohol)–bacterial cellulose nanocomposite by electrospinning for wound healing applications

    , Article Physica Status Solidi (A) Applications and Materials Science ; Volume 217, Issue 6 , 2020 Zeaiean Firouzabadi, P ; Ghanbari, H ; Mahmoudi, N ; Haramshahi, S. M. A ; Javadpour, J ; Sharif University of Technology
    Wiley-VCH Verlag  2020
    Abstract
    Polymer-based composites are used for wound healing applications. This work aims to prepare an inorganic-polymer nanocomposite based on bentonite, poly(vinyl alcohol), and bacterial cellulose by electrospinning for wound healing. The nanocomposite is synthesized using a solution intercalation technique, with 1–2 wt% nanobentonite concentration variation. The effects of commercial and laboratory-synthesized nanobentonite as well as the extract of the green walnut shell (EGWS) are examined and characterized by different techniques. The addition of nanobentonite increases the average size of fibers and tensile strength up to 200 nm and more than 15 MPa, respectively, due to the presence of... 

    Fabrication of Porous Gelatin-based Scaffold and Evaluation of Effect of Gamma Irradiation

    , M.Sc. Thesis Sharif University of Technology Vahidi, Milad (Author) ; Forounchi, Massoud (Supervisor) ; Dadbin, Susan (Supervisor)
    Abstract
    Biocompatible porous polymeric scaffolds provide a suitable 3-D environment for proliferation of stem cells in human body. For instance, growth and proliferation concurrent with differentiation of stem cells in such scaffolds can regenerate the tissues or organs. In this attitude we fabricated a porous Gelatin-based scaffold using both of freeze-drying and freeze-extraction methods.Also, effect fo gamma irradiation on microstructure of scaffolds was investigated. In addition, poly(ethylene glycol) was employed to make the scaffold softer. Moreover, effects of various parameters including freezing temperature, cross-linking agent concentration, gelatin and PEG concentrations and their... 

    Fabrication and Chracatization of Novel Electrospun Chitosan Fibers Reinforced with Bacterial Cellulose and Nanodiamond for Wound Dressing Applications

    , M.Sc. Thesis Sharif University of Technology Ostadhossein, Fatemeh (Author) ; Simchi, Abdolreza (Supervisor)
    Abstract
    Chronic wounds are among the serious injuries which have called the attention of scientists to invest in an effort to fabricate temporary skin grafts and wound dressing materials. One of the widely acceptable solutions to this obstacle is to design a bioactive scaffold capable of regenerating tissue as well as delivering active agents to the site specific area. To this end, natural biopolymers are considered as suitable candidates to be employed in regenerative medicine due to their excellent biocompatibility. In addition, nanoparticles possess special properties such as the ability in sequestering the drug release which make them promising candidates in the fabrication of the... 

    Fabricating Scaffold by Electrospinning with Natural Polymers for Creating Skin Wound Dressings

    , M.Sc. Thesis Sharif University of Technology Yousefi Zowj, Farnaz (Author) ; Alemzadeh, Iran (Supervisor) ; Vosoughi, Manouchehr (Supervisor)
    Abstract
    Skin, the largest organ in the body, presents sophisticated functions for maintaining the structural integrity of the entire body. Skin can regulate the temperature of the body, protect the body against microorganisms, have a sensory function, and produce vitamin-D through UV exposure when in direct sunlight.Due to the self-healing property of skin tissue, skin can be repaired by itself. Nevertheless, if extensive skin loss happens, owing to diabetic ulcers or deep burns, skin will not be able to repair the wound by itself. Therefore, it will lose its functions, and the fabrication of a skin equivalent will be necessary. These skin equivalents will cover the wound, regenerate the native... 

    Electrospinning of nanodiamond-modified polysaccharide nanofibers with physico-mechanical properties close to natural skins

    , Article Marine Drugs ; Volume 14, Issue 7 , 2016 ; 16603397 (ISSN) Mahdavi, M ; Mahmoudi, N ; Rezaie Anaran, F ; Simchi, A ; Sharif University of Technology
    MDPI AG 
    Abstract
    Electrospinning of biopolymers has gained significant interest for the fabrication of fibrous mats for potential applications in tissue engineering, particularly for wound dressing and skin regeneration. In this study, for the first time, we report successful electrospinning of chitosan-based biopolymers containing bacterial cellulous (33 wt %) and medical grade nanodiamonds (MND) (3 nm; up to 3 wt %). Morphological studies by scanning electron microscopy showed that long and uniform fibers with controllable diameters from 80 to 170 nm were prepared. Introducing diamond nanoparticles facilitated the electrospinning process with a decrease in the size of fibers. Fourier transform infrared... 

    Temporary skin grafts based on hybrid graphene oxide-natural biopolymer nanofibers as effective wound healing substitutes: pre-clinical and pathological studies in animal models

    , Article Journal of Materials Science: Materials in Medicine ; Volume 28, Issue 5 , 2017 , 73 ; 09574530 (ISSN) Mahmoudi, N ; Eslahi, N ; Mehdipour, A ; Mohammadi, M ; Akbari, M ; Samadikuchaksaraei, A ; Simchi, A ; Sharif University of Technology
    Springer New York LLC  2017
    Abstract
    Abstract: In recent years, temporary skin grafts (TSG) based on natural biopolymers modified with carbon nanostructures have received considerable attention for wound healing. Developments are required to improve physico-mechanical properties of these materials to match to natural skins. Additionally, in-deep pre-clinical examinations are necessary to ensure biological performance and toxicity effect in vivo. In the present work, we show superior acute-wound healing effect of graphene oxide nanosheets embedded in ultrafine biopolymer fibers (60 nm) on adult male rats. Nano-fibrous chitosan-based skin grafts crosslinked by Genepin with physico-mechanical properties close to natural skins were... 

    A comparative study of wound dressings loaded with silver sulfadiazine and silver nanoparticles: In vitro and in vivo evaluation

    , Article International Journal of Pharmaceutics ; Volume 564 , 2019 , Pages 350-358 ; 03785173 (ISSN) Mohseni, M ; Shamloo, A ; Aghababaie, Z ; Afjoul, H ; Abdi, S ; Moravvej, H ; Vossoughi, M ; Sharif University of Technology
    Elsevier B.V  2019
    Abstract
    In the current study, two series of antimicrobial dressings conjugated with silver sulfadiazine (SSD) and silver nanoparticles (AgNPs) were developed and evaluated for chronic wound healing. Highly porous polycaprolactone (PCL)/polyvinyl alcohol (PVA) nanofibers were loaded with different concentrations of SSD or AgNPs and compared comprehensively in vitro and in vivo. SSD and AgNPs indicated a strong and equal antimicrobial activity against S. aureus. However, SSD had more toxicity against fibroblast cells over one week in vitro culture. An in vivo model of wound healing on male Wistar rats was developed with a full thickness wound. All the wound dressings indicated enough flexibility and...