The thermodynamic study of interaction between folic acid and<br/>Cu(L) 2 (L=gly, ala, val )

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The thermodynamic study of interaction between folic acid and
Cu(L) 2 (L=gly, ala, val )

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Type of Document: M.Sc. Thesis
Language: Farsi
Document No: 39971 (03)
University: Sharif University of Technology
Department: Chemistry
Advisor(s): Mohammadi Boghaei, Davar
Abstract:
The complexation between folic acid and the complexes of Cu(L)2 (L = Glycine, Alanine, Valine) were investigated using UV.Vis spectroscopy. The values of the equilibrium constant K and molar absorption coefficient Ɛ of the complexes were estimated in the aquation environment at various temperatures. The temperature dependence of the K can be used for the determination of the thermodynamic reaction quantities (∆G, ∆H, ∆S) for linear regression fits to the Van’t Hoff equation. The kinetic studies reveals that the stoichiometry of reaction were 1:1 for these systems. All reaction were endothermic and the values of the ∆H are positive. In all cases entropy increased and the values of the ∆S were positive. The formation constants of these complexes were in the range of (105-106). The equilibrium constants vary among complexes at various temperature of study. The trend of ∆H and ∆S for interaction between folic acid and Cu(L)2 decreases as follow: cis- Cu(Gly)2 > trans- Cu(Gly)2 > Cu(ala)2 > Cu(val)2 The results can be explained in terms of the steric effect as well as solvation effect.
Keywords:
Folic Acid (FA) ; Spectrometry ; Complexation ; Copper II-Aminoacid Complexes

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