Preparation of Nanoparticles Based on Hyperbranched Polyglycerol as Anti Cancer Drug Delivery Systems

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Yazdi, Mojtaba | 2011

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Type of Document: M.Sc. Thesis
Language: Farsi
Document No: 42251 (03)
University: Sharif University of Technology
Department: Chemistry
Advisor(s): Pourjavadi, Ali; Adeli, Mohsen
Abstract:
Successful formulation development for poor water soluble drugs is a critical, long-standing and challengeable problem in cancer treatment. One of the methods for transporting low-soluble drugs is using nanoparticles which are able to pass through capillary walls of tumor tissues due to their small size. An example of the nanoparticles is micelle systems. Functionalized β-cyclodextrin (β-CD) by hyper branched polyglycerol (HPG) can dissolve low-soluble compounds. This polymer can be used in preparing micelles. In this project, β-cyclodextrin (β-CD) by anionic reactions is initiator for polymerization of glycidol monomer. Hydrophobic cavity of the β-cyclodextrin (β-CD) in placing the phenyl of polymer polystyrene is used and then micelles are made. By atomic force microscope (AFM), existence of two phases is confirmed. These phases include polystyrene and the HPG-g-CD polymers. Dimensions of the particles by transmission electron microscopy (TEM) is determined 100 to 150 nm which is appropriate for crossing nanoparticles from capillary wall of cancer tissues. TGA and DTG thermograms indicate formation of nanoparticles and their interaction between them in creating their structures
Keywords:
Nanoparticles ; Polyglycirol ; Beta-Cyclodextrin ; Polystyrene ; Pacli Taxel (PTX)

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