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Study and Synthesis of Biocompatible Polymer and Loading of Peptide Drug for using in Drug Delivery

Nikravesh, Niusha | 2013

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  1. Type of Document: M.Sc. Thesis
  2. Language: Farsi
  3. Document No: 44944 (06)
  4. University: Sharif University of Technology
  5. Department: Chemical and Petroleum Engineering
  6. Advisor(s): Vosoughi, Manouchehr; Alemzadeh, Iran
  7. Abstract:
  8. With the rapid development of biotechnology, peptide and protein drugs are now playing an increasingly important role in therapeutics. Compared with chemical drugs, peptide and protein drugs have some limitations such as low stability and rapid deactivation. Biodegradable and biocompatible polymeric micro carriers have been shown to have a high potential for the delivery of peptides and proteins. Among these polymers, alginate has been widely investigated as a biomaterial. Alginates are natural polysaccharide polymers isolated from brown seaweed. Bovine serum albumin (BSA) loaded calcium alginate microspheres produced in this study by a modified w/o emulsification method. The influence of the preparation conditions on the encapsulation efficiency, microspheres size and morphology and finally drug release profile was investigated.
    Most micro particles exhibited spherical and fairly smooth morphology with (8.415-287.9) µm particle size. Most calcium alginate hydrogels lead to a potent burst effect and too fast protein release. To overcome these problems, composite microspheres of Alginate and carboxymethyl cellulose were produced. The results demonstrated that composite microspheres showed slower release and were able to significantly reduce the release of BSA in the first hour and the encapsulation efficiency increased to 92.218%. Therefore, this method can be applied to prepare composite alginate microspheres which could be an optimal system for the controlled release of bio therapeutic molecules
  9. Keywords:
  10. Alginate ; Carboxymethyl Cellulose ; Microspheres ; Bovine Serum Albumin (BSA) ; Piptide Drugs ; Biocompatible Polymer ; Drug Delivery

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