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Facile synthesis of highly substituted 2-pyrone derivatives via a tandem Knoevenagel condensation/lactonization reaction of β-formyl-esters and 1,3-cyclohexadiones

Moghaddam, F. M ; Sharif University of Technology

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  1. Type of Document: Article
  2. DOI: 10.1016/j.tetlet.2014.02.104
  3. Abstract:
  4. A mild and efficient tandem process for the synthesis of new highly substituted 2-pyrones starting from commercially available 2-arylacetic acids has been developed. The synthesis is based on the Knoevenagel condensation of 1,3-cyclohexadiones with various β-formyl-esters, followed by lactonization in the presence of nano ZnO (20 mol %). Moderate to high yields and readily available cheap starting materials are the key features of the present method
  5. Keywords:
  6. 2-Pyrone derivatives ; Knoevenagel condensation ; Lactonization ; ZnO nanoparticles ; β-Formyl-esters ; 2 pyrone derivative ; 5,5 dimethyl 1,3 cyclohexanedione ; Cyclohexane derivative ; Ester derivative ; Ketone derivative ; Nanoparticle ; Catalyst ; Chemical analysis ; Chemical procedures ; Nanocatalyst ; Substitution reaction ; Synthesis
  7. Source: Tetrahedron Letters ; Vol. 55, issue. 18 , April , 2014 , p. 2908-2911 ; ISSN: 00404039
  8. URL: http://www.sciencedirect.com/science/article/pii/S0040403914003566