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Cytotoxicity of protein corona-graphene oxide nanoribbons on human epithelial cells

Mbeh, D. A ; Sharif University of Technology

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  1. Type of Document: Article
  2. DOI: 10.1016/j.apsusc.2014.09.155
  3. Abstract:
  4. Graphene oxide nanoribbons (GONRs) were synthesized using an oxidative unzipping of multi-walled carbon nanotubes. The interactions of the GONRs with various concentrations of fetal bovine serum or human plasma serum indicated that the GONRs were functionalized substantially by the albumin originated from the two different protein sources. Then, concentration-dependent cytotoxicity of the protein-functionalized GONRs on human epithelial cells was studied. Although the GONRs with concentrations ≤50 μg/mL did not exhibit significant cytotoxicity on the cells (with the cell viability >85%), the concentration of 100 μg/mL exhibited significant cytotoxicity including prevention of cell proliferation and induction of cell apoptosis. These results can provide more in-depth understanding about cytotoxic effects of graphene nanostructures which can be functionalized by the proteins of media
  5. Keywords:
  6. Cytotoxicity ; Graphene oxide ; Human cells ; Nanoribbons ; Protein corona ; Body fluids ; Cell death ; Cell proliferation ; Graphene ; Multiwalled carbon nanotubes (MWCN) ; Proteins ; Yarn ; Concentration-dependent ; Cytotoxic effects ; Fetal bovine serum ; Graphene oxides ; Human epithelial cells ; In-depth understanding ; Protein coronas
  7. Source: Applied Surface Science ; Volume 320 , 30 November , 2014 , Pages 596-601 ; ISSN: 01694332
  8. URL: http://www.sciencedirect.com/science/article/pii/S0169433214021461