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Hydrophobic nanocarriers embedded in a novel dual-responsive poly(N-isopropylacrylamide)/chitosan/(cyclodextrin) nanohydrogel

Bashari, A ; Sharif University of Technology | 2013

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  1. Type of Document: Article
  2. DOI: 10.1007/s10965-013-0256-8
  3. Publisher: 2013
  4. Abstract:
  5. The incorporation of modified β-cyclodextrin (β-CD) into a poly(N-isopropylacrylamide) (PNIPAAm)/chitosan (PNCS) nanohydrogel was studied. β-CD was functionalized with acrylic groups, with different numbers of vinyl bonds added per β-CD molecule. The surfactant-free dispersion polymerization (SFDP) semi-batch method was used to synthesize the nanohydrogel. Increasing the number of vinyl groups per β-CDAC (β-CD acrylate) molecule induced the formation of smaller nanogels with diameters ranging from 142 to 68 nm. The cyclodextrin-modified dual-responsive nanogels obtained presented an LCST (lower critical solution temperature) in aqueous medium at around 31 C. The incorporation of β-CDAC into the nanohydrogel networks was demonstrated using the phenolphthalein titration method. The diameters of the nanohydrogels changed upon varying the pH and temperature of the swelling medium. In order to investigate the release behavior of the nanohydrogels, methylene blue and phenolphthalein were employed as hydrophilic and hydrophobic model drugs. The results showed that the drug loading achieved with the hydrophobic drug was higher than that achived with the hydrophilic drug. The properties of the final nanohydrogels were investigated with FTIR, FESEM, CHNO analysis, DSC, and DLS
  6. Keywords:
  7. Cyclodextrin ; Nanohydrogel ; PNIPAAm ; Stimuli-responsive polymer ; Hydrophilic and hydrophobic ; Lower critical solution temperature ; Nanohydrogels ; PNIPAAm ; Poly-n-isopropyl acrylamide ; Release behaviors ; Stimuli-responsive polymer ; Surfactant-free dispersions ; Acrylic monomers ; Aromatic compounds ; Biomaterials ; Chitosan ; Cyclodextrins ; Functional polymers ; Hydrophilicity ; Hydrophobicity ; Molecules ; Nanostructured materials ; Organic polymers ; Titration ; Loading
  8. Source: Journal of Polymer Research ; Volume 20, Issue 10 , 2013 ; 1572-8935 (Online ISSN)
  9. URL: http://link.springer.com/article/10.1007%2Fs10965-013-0256-8