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Computational investigation of sulphate diffusion into the dog disc

Motaghinasab, S ; Sharif University of Technology | 2011

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  1. Type of Document: Article
  2. DOI: 10.1109/ICBME.2011.6168547
  3. Publisher: 2011
  4. Abstract:
  5. We proposed a model to investigate the transient diffusion of drug (sulphate) into the intervertebral disc. Using finite element method, drug diffusion was simulated and the concentration of diffused drug in each region of disc including Nucleus pulpous (NP), Inner annulus fibroses (IA), and Outer annulus fibroses (OA) was measured. In addition, to investigate the role of CEP permeability on the amount of diffused drug, model was simulated with different cartilage endplate (CEP) permeability. Having obtained concentration distribution for different cases, it was clearly shown that the amount of diffused drug is affected by the endplate permeability and the more permeable CEP, the more diffused drug into the disc specifically at the center of the disc
  6. Keywords:
  7. sulphate ; Cartilage endplate ; Computational investigation ; Concentration distributions ; Drug diffusion ; Endplates ; Intervertebral discs ; Sulphates ; Transient diffusion ; Biomedical engineering ; Diffusion ; Finite element method ; Sulfur compounds ; Computer simulation
  8. Source: 2011 18th Iranian Conference of Biomedical Engineering, ICBME 2011, 14 December 2011 through 16 December 2011 ; December , 2011 , Pages 161-164 ; 9781467310055 (ISBN)
  9. URL: http://ieeexplore.ieee.org/xpl/articleDetails.jsp?arnumber=6168547