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Computer modeling of drug distribution after intravitreal administration

Haghjou, N ; Sharif University of Technology | 2011

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  1. Type of Document: Article
  2. Publisher: 2011
  3. Abstract:
  4. Intravitreal injection (IVI) is the most common treatment for eye posterior segment diseases such as endopthalmitis, retinitis, age-related macular degeneration, diabetic retinopathy, uveitis, and retinal detachment. Most of the drugs used to treat vitreoretinal diseases, have a narrow concentration range in which they are effective, and may be toxic at higher concentrations. Therefore, it is critical to know the drug distribution within the eye following intravitreal injection. Having knowledge of drug distribution, ophthalmologists can decide on drug injection frequency while minimizing damage to tissues. The goal of this study was to develop a computer model to predict intraocular concentrations and pharmacokinetics of intravitreally injected drugs. A finite volume model was created to predict distribution of two drugs with different physiochemical properties in the rabbit eye. The model parameters were obtained from literature review. To validate this numeric model, the in vivo data of spatial concentration profile from the lens to the retina were compared with the numeric data. The difference was less than 5% between the numerical and experimental data. This validation provides strong support for the numerical methodology and associated assumptions of the current study
  5. Keywords:
  6. Age-related macular degeneration ; Computer modeling ; Computer models ; Concentration ranges ; Diabetic retinopathy ; Drug distribution ; Drug injection ; Experimental data ; Finite volume model ; In-vivo ; Intraocular ; Intravitreal injection (IVI) ; Literature reviews ; Model parameters ; Modelling ; Numeric data ; Numeric models ; Numerical methodologies ; Physio-chemical properties ; Posterior segment ; Spatial concentration ; Vitreoretinal disease ; Eye protection ; Finite volume method ; Ophthalmology ; Pharmacokinetics ; Tissue ; Models ; Drug therapy
  7. Source: World Academy of Science, Engineering and Technology ; Volume 77 , 2011 , Pages 706-716 ; 2010376X (ISSN)
  8. URL: http://waset.org/publications/103/computer-modeling-of-drug-distribution-after-intravitreal-administration