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Contribution of nonlocal interactions to DNA elasticity

Eslami Mossallam, B ; Sharif University of Technology | 2011

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  1. Type of Document: Article
  2. DOI: 10.1063/1.3567185
  3. Publisher: 2011
  4. Abstract:
  5. A nonlocal harmonic elastic rod model is proposed to describe the elastic behavior of short DNA molecules. We show that the nonlocal interactions contribute to effective bending energy of the molecule and affect its apparent persistence length. It is also shown that the anomalous behavior which has been observed in all-atom molecular dynamic simulations [A. K. Mazur, Biophys. J. 134, 4507 (2006)] can be a consequence of both nonlocal interactions between DNA base pairs and the intrinsic curvature of DNA
  6. Keywords:
  7. Anomalous behavior ; Bending energies ; DNA base pairs ; DNA elasticity ; DNA molecules ; Elastic behavior ; Elastic rod ; Intrinsic curvature ; Molecular dynamic simulations ; Non-local interactions ; Nonlocal ; Persistence length ; Elasticity ; Molecular dynamics ; Nucleic acids ; Base pairing ; Chemical model ; Chemistry ; Conformation ; Computer Simulation ; DNA ; Models, Chemical ; Monte Carlo Method ; Nucleic Acid Conformation
  8. Source: Journal of Chemical Physics ; Volume 134, Issue 12 , 2011 ; 00219606 (ISSN)
  9. URL: http://scitation.aip.org/content/aip/journal/jcp/134/12/10.1063/1.3567185