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Simulation of Ultrasound Waves Propagation in Soft Tissue in Cancer Treating by HIFU

Molayi, Hanif | 2016

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  1. Type of Document: M.Sc. Thesis
  2. Language: Farsi
  3. Document No: 48417 (08)
  4. University: Sharif University of Technology
  5. Department: Mechanical Engineering
  6. Advisor(s): Ahmadiyan, Mohammad Taghi; Firoozbakhsh, Keikhosrow
  7. Abstract:
  8. Nowadays cancer has become one of the main and prevailing worldwide challenges in medical field, and many attempts have been made for treatment of this disease. The common methods for cancer treatment, have had significant side effects and even resulted death. The method of “High Intensity Focused Ultrasound” (HIFU) as a non-invasive method, has been welcomed by engineers and doctors and is using in some tumor based cancers. For predicting the level of temperature increasing in tissue, it’s necessary to model the ultrasound waves propagates from HIFU source precisely. The main object of this thesis is modeling and simulation of the behavior of ultrasound wave propagation and investigating the effect of these waves on tissue, and amount of absorption and generated heat, by focusing of the waves on the target point. Ultrasound waves are high frequency acoustic waves that are very useful in medical fields. The frequency of the waves used in HIFU ranging between 1 and 4 MHz. Ultrasound waves have usually nonlinear nature, and as a result modeling of sound propagation are taken place by nonlinear wave equation too. In this thesis, modeling has been made by the Westervelt's equation. This equation takes into account the effect of absorption and attenuation causing increase in environmental temperature, and can calculate amount of absorbed heat by environment. The modeling and simulation of the Westervelt's equation and Bioheat transfer equation has been performed under Comsol Multiphysics software that solve equations by finite element method. The results in this project demonstrate focus of energy in the waves propagation source focal point very well and guarantee that surrounding cells are less damaged comparing to the focal point
  9. Keywords:
  10. Ultrasonic Waves ; Cancer ; Cancer Treatment ; Finite Element Method ; High Intensity Focused Ultrasound (HIFU)Method

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