Sharif Digital Repository

Best cancer treatment is the one which reduces the tumor density in minimum time and side effects, considering the input limitations. In this paper, tracking controller and robust controllers are designed to achieve the mentioned objectives, simultaneously. An ODE-based mathematical model of the human body under chemovirotherapy is selected, which includes the uninfected and infected tumor cells, free viruses, immune cells, and a chemotherapeutic drug. For tracking purposes, a servo controller based on the entire eigenstructure assignment (EESA) approach is applied to the model, continuously and discretely. For robust purposes H-infinity and D-K iteration approaches are implemented and... 

In recent years, many efforts have been made in the field of drug delivery with hydrogel nanoparticles. This class of materials has been at the center of attention in medical science due to their improved physical and biological properties including high amount of water preservation, penetration, bio capampatibility and physical structure similar to outside matrices of tissue. Among various applications in medical sciences, drug delivery based on hydrogels is very attractive. Hydrogels can protect drugs from aggressive environmental factors such as pH and thermal changes, and presence of enzymes. The porosity of hydrogels facilitates drug loading into the gel matrix and provides a... 

In this project, we have assessed the electrochemical treatment method. In this method, pH decrease of the place where a tumor is located engenders the necrosis of cancer cells and consequently they are destroyed. The process of pH decrease is caused by exerting voltage on electrods that are located near the tumor. The aims of optimizing this methods are to minimize the pH that results in the increase of cancer cell annihilation and to minimize the HClO and Cl2 products which are toxic and chage the healthy tissues to cancer cells. In this project, the model of electrochemical treatment method is explained, and then this model is simulated using the parametes which are provided in the... 

Cancer is one of the most critical diseases in the last century. Numerous efforts have been conducted to treat cancer. According to the report of World Health Organization, one death of every six deaths is due to this disease. More than 100 cancer types have been identified. Among these types, CNS tumor is one of the most critical cancer types with high mortality (65.9%). Various methods have been applied to treat this disease, but still, treatment efficiency is low. In this thesis, the effect of ultrasound waves on drug delivery into CNS tumors was evaluated using both experimental and simulation devices. A syringe pump was used to inject the drug solution into tissue-mimicking gels (CED).... 

Drug delivery systems (DDS), which, are sensitive to tumor medium have high importance. one of the most important problem of current treatment of cancer is damage of the normal tissue, which, it is expected to solve by smart drug delivery systems. In such cases, one or more features of cancer medium cause to release of the drug. One of features of cancer medium is high concentration of reactive oxygen species and hydrogen peroxide in the most common between them. The purpose of this study is to build a drug delivery system, which it is sensitive to hydrogen peroxide. This carrier has 4 main parts. The first part is anti-cancer drug, which, it is located in the carrier. Second part is... 

Statistics show that cancer is the second leading cause of death in the world. In recent years, several studies have shown that combination therapy is more effective than single therapy. Modeling and simulation the dynamics of cancer and the immune system and controlling the dose of cancer drugs complement preclinical trials. The aim of this study was to apply the model predictive control approach to determine the optimal dose of chemotherapy and immunotherapy drugs to treat cancerous tumors. Thus, with a preliminary analysis of the analytics, a six-state dynamic model has been selected as a hypothetical patient to advance therapeutic goals. Two sets of parameters for the hypothetical... 

Cancer is one of the leading causes of death around the world according to WHO. Scientists’ tried different approaches for treating this illness and from about 100 years ago one of the leading approaches to treat cancer is radiotherapy. With advancement of technology possibility of using different kinds of radiation for this purpose became available and one of the most interesting ones is high energy charged ions. But using high energy charged ions for treatment planning needs deep understanding of its nature and factors that affects the human body cells response to it. This thesis briefly reviewed the working principles of radiation therapy and then investigated two of the most used... 

Nowadays cancer has become one of the main and prevailing worldwide challenges in medical field, and many attempts have been made for treatment of this disease. The common methods for cancer treatment, have had significant side effects and even resulted death. The method of “High Intensity Focused Ultrasound” (HIFU) as a non-invasive method, has been welcomed by engineers and doctors and is using in some tumor based cancers. For predicting the level of temperature increasing in tissue, it’s necessary to model the ultrasound waves propagates from HIFU source precisely. The main object of this thesis is modeling and simulation of the behavior of ultrasound wave propagation and investigating... 

Recent drug delivery strategies have attempted to maximize the concentration of chemotherapeutic molecules into the tumors, while minimizing their systemic distribution. Doxorubicin has been widely used for a variety of cancers, successfully producing regression in acute leukaemia, lymphomas, soft-tissue and osteogenic sarcomas, paediatric malignancies and adult solid tumours, in particular breast and lung carcinomas. Common adverse effects of doxorubicin include hair loss, myelosuppression, nausea and vomiting, oral mucositis, oesophagitis, diarrhoea, skin reactions and serious reactions include hypersensitivity reactions, radiation recall, heart damage and liver dysfunction. Chitosan has... 

Currently, the HIFU (High Intensity Focused Ultrasound) therapy method is known as one of the most advanced surgical techniques in tumor ablation therapy. Simulation of the HIFU therapy in the case of appearance of bon barrier is essential in HIFU planning to improve the usefulness and efficiency of treatment in brain tumor cases. In this work, linear, thermoviscous equations are applied for simulation of phase correction array and steering method, after analysis of performance, these methods are used in a 3D human brain and skull model to estimate thermal ablation in case of using these methods. Results indicate that the maximum focal pressure of 1.42 and 1.65 MPa can be achieved for... 

The main methods have been used clinically for cancer treatment are included: surgery, chemotherapy, radiation therapy and hyperthermia. Hyperthermia (heat therapy) treatment method in which by raising the temperature of the tumor it removed. Magnetic hyperthermia is known as a kind of hyperthermia that have been represent appropriate results. In this study, using iron oxide nanoparticle coated with graphene for cancer treatment under a magnetic field of the laser. In the first stage, graphene oxide nanosheets and nanoparticles Magntayt are synthesized by chemical oxidation and co-precipitation, respectively. At the end, the nanoparticles on the substrate of graphene layer is obtained... 

Low frequency Magnetic hyperthermia is a promising cancer treatment technique. It is based on the fact that magnetic nanoparticles (MNPs) placed in an alternating magnetic field release heat.Active research is being done to improve the specific absorption rate (SAR) of MNPs, which could permit the treatment of tumors of a smaller size and could reduce the amount of material that must be injected to treat a tumor of a given size. However, a major technical problem with hyperthermia is the difficulty of heating the targeted tumor to the desired temperature without damaging the surrounding tissues, as the electromagnetic energy must be directed from an external source and penetrates normal... 

Hyperthermia (also called thermal therapy or thermotherapy) is defined as a type of cancer treatment in which body tissue is exposed to high temperatures, to damage and kill cancer cells, or to make cancer cells more sensitive to the effects of radiation and certain anticancer drugs. The temperature increase required by hyperthermia can be achieved via different heat sources, such as electromagnetic radiation waves (radiofrequency or microwave, ultrasound waves and electrical current. These techniques have shown good results, however, the major problem with present conventional methods is reaching homogenous heat distribution and therapeutic temperatures in the deep region of the tumor to be... 

Cancer treatment is one of the most challenging issues of recent years. Extensive researches have been conducted in various fields of medicine, pharmacy, and medical physics in this regard. Today, considering nanotechnology developments, researchers believe that full cancer treatment is possible through the use of nano-systems designed with scientific background to overcome the defects of previous methods. In this research, the main purpose is to design and synthesize multifunctional hybrid nanostructures with favorable optical and magnetic properties providing a way to combine chemotherapy and thermal treatment. Accordingly, two different structures were designed and experimentally... 

One of the major problems in cancer treatment is side effects of treatments. Today, scientists have developed smart nanocarrier for diagnosis and drug delivery that can circulate in the bloodstream, pass the body's immune system to kill cancer cells and attach to the cancer cells to deliver drugs, without the side effects that are in other treatments, such as chemotherapy. magnetic nanoparticles coated by biodegradable polymers are one of the smart polymers. In this study, iron oxide nanoparticles with amine group on their surface are coated by starch modified by methyl acrylate then reacted with hydrazine and hydrazide functional group is formed that can chemically be bonded with the... 

As a method of cancer treatment or improvement of cancer-related complications, external radiation therapy is prescribed by physicians, in case of detection of a tumor in a region of patient’s body. Over time, various techniques have been developed for external beam radiation therapy. Among which, Intensity Modulated Radiation Therapy (IMRT), due to its ability to adjust the intensity of radiation beams, has a higher capacity to generate appropriate dose distribution based on tumor size and volume and it is one of the most widely used techniques in cancer treatment centers.The core process in treatment planning is using appropriate computer algorithms which results in posing enough damage to... 

Sonodynamic therapy has been developed over the last century, now it has become more widely used as a medical tool for the treatment of various diseases such as cancer. This technique involves delivery of sonosensitizing drugs, irradiation of ultrasound waves and motivation of drugs. In this thesis surface modification process with polymer and biocompatible surfactant on TiO2 nanoparticles has been done due to stabilization of TiO2 nanoparticles in neutral pH which is similar to inside-body situation. In the last step, for cancer therapy, doxorubicin as a cancer drug was loaded on TiO2 which was surface modified by PVA. The results revealed the best ratio of (PVA: TiO2), (SDS: TiO2), (SDS:... 

Nowadays, chemotherapy is one of the common ways to treat cancer. Although, chemotherapy is used to kill cancer cells , chemotherapy drugs also target healthy cells and tissues of the body. In practice, it is difficult to strike a balance between injectable doses of drugs and toxicity in the body, and physicians are always looking for an effective treatment plan. One of the most common drugs that physicians use in chemotherapy is cell-cycle-specific drugs. These types of chemotherapy drugs affect only a certain phase of cell cycle and to a certain extent. Since the lifetime of the cancer cells is uncertain, the effective use of these drugs depends on the correct injection time of the drugs... 

owning to the side effects and disadvantages of conventional methods of cancers treatments such as chemotherapy, currently, scientists are attempting to find new methods to replace them. Furthermore, many human diseases like SCID and Hemophilia are due to genetic disorders and scientists are also seeking to find permanent treatments instead of available temporary ones for them. in recent years, regarding the obtained achievement, Gene Therapy is being considered as a promising method for both cancers and genetic disorders treatment. But due to low efficiency of this method at this stage, there is an endevour among researchers for a more profound comprehension of the basics of gene therapy to... 

The purpose of this study is to estimate the temperature distribution of the internal body organs using electromagnetic waves. When the external electromagnetic field propagates in biological tissues under a process like microwave hyperthermia, the temperature of the tissue at the field concentration area increases. Due to temperature and frequency dependence of the tissue dielectric, the tissue permittivity changes; thus, the electric field scattered by the tissue changes. Therefore, by measuring the field scattered from the object, dielectric changes of the tissue structure can be calculated. Since the biological tissues’ dielectric coefficient at frequencies lower than 2GHz is linear,...