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Acoustic Streaming for Drug Delivery into Brain Tissue

Boroumand, Ahmad | 2019

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  1. Type of Document: M.Sc. Thesis
  2. Language: Farsi
  3. Document No: 52810 (08)
  4. University: Sharif University of Technology
  5. Department: Mechanical Engineering
  6. Advisor(s): Assempour, Ahmad; Ahmadian, Mohammad Taghi
  7. Abstract:
  8. Cancer is one of the most critical diseases in the last century. Numerous efforts have been conducted to treat cancer. According to the report of World Health Organization, one death of every six deaths is due to this disease. More than 100 cancer types have been identified. Among these types, CNS tumor is one of the most critical cancer types with high mortality (65.9%). Various methods have been applied to treat this disease, but still, treatment efficiency is low. In this thesis, the effect of ultrasound waves on drug delivery into CNS tumors was evaluated using both experimental and simulation devices. A syringe pump was used to inject the drug solution into tissue-mimicking gels (CED). Then, Array HIFU Transducers with the resonance frequency of 1 MHz were utilized to concentrate the waves in the focal region in order to penetrate the injected drugs. Results show that ultrasound waves can improve drug volume distribution over six times in comparison to CED. Moreover, with solving the equations of acoustic streaming in soft tissue via FEM software COMSOL Multiphysics 5.3, it has been shown that these equations have the ability to simulate the drug penetration into brain tissue with the relative errors: 20%, 12.5%, and 10.25 %
  9. Keywords:
  10. Drug Delivery ; Ultrasonic Waves ; Finite Element Method ; Brain Tumor ; Cancer Treatment ; Acoustic Streaming

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