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Design and Fabrication of a Microfluidic System Based on Dielectrophoresis for Enrichment and Separation of Bioparticles

Rahmani, Ali | 2016

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  1. Type of Document: M.Sc. Thesis
  2. Language: Farsi
  3. Document No: 49190 (06)
  4. University: Sharif University of Technology
  5. Department: Chemical and Petroleum Engineering
  6. Advisor(s): Mohammadi, Ali Asghar
  7. Abstract:
  8. The main purposes of this project are simulation, design, and fabrication of a microfluidic system based on dielectrophoresis (DEP) exploiting AC voltages for separation of microparticles. Generally, this project can be divided into two parts. First, the engineering section including design and fabrication of microchip, and second biological samples preparation for investigating the system performance. The main advantages of proposed system are eliminating joule heating, a significant problem in insulating based dielectrophoresis systems, overcoming problems related to metal contamination in biological samples, the main problem of conventional dielectrophoresis platforms, and removing complexity of presented contactless dielectrophoresis platforms like adjusting electric properties of liquid electrodes. The principal operating concepts of the presented system lays in differences in electric properties of bioparticles. Finally, for investigating the performance of the fabricated system, solutions including yeast, E-coli, and latex particles were injected into the system and the effects of voltage, frequency, and flow rate on enrichment and separation index were studied
  9. Keywords:
  10. Simulation ; Separation ; Experiments Design ; Dielectrophoresis Technique ; Microfluidic System ; Bioparticles

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