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Redox-sensitive smart nanosystems for drug and gene delivery

Karimi, M ; Sharif University of Technology

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  1. Type of Document: Article
  2. DOI: 10.2174/1385272820666160510154557
  3. Publisher: Bentham Science Publishers B.V
  4. Abstract:
  5. Background: Smart stimulus-responsive nanocarriers represent a rapidly growing class of drug-delivery systems for cancer and other diseases. Objective: The alterations of redox potential between the intracellular environment and the extracellular space have been widely utilized as a trigger for delivery of therapeutic agents by smart stimulus-responsive nanocarriers. We set out to review the scientific literature. Method: Published papers between 1980 and the present day were surveyed. Results: The advantages of redox-activated smart delivery of drugs, genes, and imaging agents include: the amplitude of the redox-responsive signal; the simple chemical features needed to trigger the activation process; and the relative simplicity of preparing these nanocarriers with an integrated redox-sensitive triggering element. Redox-sensitive nanovehicles are often sensitive to glutathione (GSH) as a regulator of cellular redox potential, which is a very important redox couple in mammalian cells. Other nanostructures can be designed to respond to oxidation, which may be useful for drug-delivery to sites with oxidative stress. Conclusion: Redox-responsive nanocarriers are a prominent member of the class of smart nanocarriers, and are expected to grow importance in coming years
  6. Keywords:
  7. Drug delivery ; Glutathione ; Micelle ; Nanocapsule ; Nanogel ; Polymersome ; Redox-Sensitive
  8. Source: Current Organic Chemistry ; Volume 20, Issue 28 , 2016 , Pages 2949-2959 ; 13852728 (ISSN)
  9. URL: http://benthamscience.com/journals/current-organic-chemistry/volume/20/issue/28