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Combination of PRP (platelet Rich plasma)with Polymeric Scaffold for Cartilage Regeneration

Rafiei, Mehrnoosh | 2016

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  1. Type of Document: M.Sc. Thesis
  2. Language: Farsi
  3. Document No: 49436 (06)
  4. University: Sharif University of Technology
  5. Department: Biomedical Engineering
  6. Advisor(s): Abdekhodaei, Mohammad Jafar
  7. Abstract:
  8. The aim of this study is the fabrication of 3D porous PCL scaffolds contain core-shell fibers for cartilage tissue engineering. The novel fabrication method is co-axial wet electrospinning simultaneously. These tablets like scaffolds have superior porosity and pore sizes for cell culturing and cell-cell interaction as they have good mechanical properties for cartilage tissue engineering in comparison to 2D electrospun scaffolds. The structure of these 3D scaffolds is mimicking the ECM of cartilage. This study presents the coaxial electrospinning of PCL nanofibers encapsulated with bovine serum albumin and platelet rich plasma for demonstration of controlled release and bioactivity retention, respectively. For this purpose, different loading systems include blending, coaxial electrospinning were analyzed. In comparison to blending the coaxial electrospinning is superior and sustained protein release kinetic at least for 12 days. In conclusion, coaxial electrospinning is shown to be a versatile technique in achieving the delivery of biochemical signals in a controlled manner for regeneration of cartilage. These 3D tablets like PCL scaffolds incorporated with platelet rich in plasma are an engineered systems that mimic the nature of cartilage tissue in the best manner
  9. Keywords:
  10. Controlled Release ; Core-Shell Structure ; Cartilage Tissue Engineering ; Three Dimensional Scaffolds ; Electrospinning ; Polycaprolactone Composite

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