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Conjugation of amphotericin B to carbon nanotubes via amide-functionalization for drug delivery applications

Vossoughi, M ; Sharif University of Technology | 2009

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  1. Type of Document: Article
  2. Publisher: 2009
  3. Abstract:
  4. Carbon nanotubes are among promising components for a wide range of applications, due to their unique properties; Specifically, They are a new alternative and efficient tool for transporting and translocating therapeutic molecules since they can translocate easily into the cytoplasm or nucleus of a cell through its membrane without generating an immunogenic response and toxic effects. While pristine carbon nanotubes are insoluble in all solvents, the organic functionalisation of carbon nanotubes is the prerequisite for their solubility profiles and their manipulation into biological systems. For this purpose, in this study, we first report the Amide-functionalization of CNTs which a direct coupling of ethylene-diamine with the carboxylic groups to introduce amino groups via amide formation. Finally, these functionalized carbon nanotubes will conjugate to Amphotericin B, the most effective antibiotic though toxic in the treatment of chronic fungal infections, via a two step process of diimide-activated amidation. The whole process is characterized by FTIR, TEM, UV-vis and Kaiser test
  5. Keywords:
  6. Amphotericin B ; Carbon nanotubes ; Conjugation ; Drug delivery ; Functionalisation
  7. Source: Engineering Letters ; Volume 17, Issue 4 , 2009 ; 1816093X (ISSN)
  8. URL: http://www.engineeringletters.com/issues_v17/issue_4/EL_17_4_12.pdf