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Stereoselective synthesis ofβ-Amino ketones via direct mannich-type reaction catalyzed with SO 2- 4/TiO 2 and SO 2- 4/nano TiO 2

Samet, M ; Sharif University of Technology | 2009

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  1. Type of Document: Article
  2. DOI: 10.1080/00397910902906594
  3. Publisher: 2009
  4. Abstract:
  5. At room temperature, SO 2- 4/nano-TiO 2 efficiently catalyze the direct Mannich-type reaction of varieties of in situ-generated aldimines using aldehydes and anilines with ketones in a three-component reaction under solvent-free conditions. The reaction proceeds rapidly and affords the correspondingβ-amino ketones in good to high yields with good to excellent stereoselectivity. The catalyst can be recycled for subsequent reactions without any appreciable loss of efficiency
  6. Keywords:
  7. β-Amino ketones ; Nano-TiO 2 ; SO 4 2-/TiO 2 ; Aldehyde ; Aminoketone ; Aniline ; Beta aminoketone ; Carbonyl derivative ; Ketone ; Sulfate ; Titanium dioxide ; Unclassified drug ; Catalysis ; Catalyst ; Chemical reaction ; Infrared spectroscopy ; Mannich reaction ; Nanocatalyst ; Proton nuclear magnetic resonance ; Room temperature ; Stereochemistry ; Synthesis
  8. Source: Synthetic Communications ; Volume 39, Issue 24 , 2009 , Pages 4441-4453 ; 00397911 (ISSN)
  9. URL: https://www.tandfonline.com/doi/full/10.1080/00397910902906594