Synthesis of Graphene Aerogel for Potential Application in Drug Delivery

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Ayazi, Hossein | 2017

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Type of Document: M.Sc. Thesis
Language: Farsi
Document No: 50378 (04)
University: Sharif University of Technology
Department: Physic
Advisor(s): Akhavan, Omid; Raufi, Mohammad
Abstract:
Since the development of various anti-cancer drugs, numerous attempts have been made to decrease their off-target adverse effects anhance their efficiency.Among these efforts developing novel drug delivery systems have been demonstrate promising potentials and lots of carriers have reached the market and clinical phases.Although plentiful researches on different drug carriers, lots of problems in drug loading, release and final efficiency are yet remaind.In recent decade, graphene oxide and graphene aerogel have been attracted remarkable intrest as drug carriers, due to their biodegradable and biocompatible characteristics.Accordingly, in this study graphene aerogel have been synthesized and in vitro its loading and releasing were evaluated for the first time.Results revealed that the drug entrapment in the prepared graphene aerogel was about 98.5% which is a remarkable entrapment potential amoung different drug carriers.But unfortunately the drug release was not appropriate enough and more precise studies are required to reach an proper drug delivery system
Keywords:
Graphene ; Drug Carrier ; Aerogel Synthesis ; Drug Delivery ; Extended Release System ; Rhodamine 6G ; Anticancer Drugs

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