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A copper-catalyzed synthesis of functionalized quinazolines from isocyanides and aniline tri- and dichloroacetonitrile adducts through intramolecular C-H activation

Nematpour, M ; Sharif University of Technology

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  1. Type of Document: Article
  2. DOI: 10.1055/s-0036-15588166
  3. Abstract:
  4. A novel class of substituted quinazolines were prepared in good yields by a one-pot three-component reaction of isocyanides with adducts of anilines and tri- or dichloroacetonitrile, followed by intramolecular C-H activation, catalyzed by copper(I) iodide with l -proline as a ligand in acetonitrile at room temperature. © 2017 Georg Thieme Verlag Stuttgart .New York-Synlett
  5. Keywords:
  6. C-H activation ; Copper catalysis ; Dichloroacetonitrile ; Isocyanides ; Quinazolines ; Trichloroacetonitrile ; Carbon ; Chloroacetonitrile ; Copper ; Dichloroacetonitrile ; Hydrogen ; Isocyanide derivative ; Organic compound ; Proline ; Quinazoline derivative ; Unclassified drug ; Catalysis ; Chemical interaction ; Chemical structure ; Clinical protocol ; Concentration (parameters) ; One pot synthesis ; Purification ; Reaction optimization ; Room temperature ; Solvent effect ; Structure analysis ; Tautomerization
  7. Source: Synlett ; Volume 28, Issue 12 , 2017 , Pages 1441-1444 ; 09365214 (ISSN)
  8. URL: https://www.thieme-connect.com/products/ejournals/abstract/10.1055/s-0036-15588166