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The Fabrication of Porous Scaffolds of Polyvinyl Chloride/Polyethylene Glycol and Nano Diamonds Using Gamma Radiation for Medical Applications

Jabbar, Ali | 2018

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  1. Type of Document: M.Sc. Thesis
  2. Language: Farsi
  3. Document No: 50663 (06)
  4. University: Sharif University of Technology
  5. Department: Chemical and Petroleum Engineering
  6. Advisor(s): Frounchi, Masoud; Dadbin, Susan
  7. Abstract:
  8. Today, tissue engineering research is expanding to a large extent, so tissue engineering has the ability to build artificial organs and tissues. In this project, we have used two polymers of polyethylene glycol and polyvinyl chloride, which are used for network irradiation. After irradiation, these polymers were made by drying the freewheeling porous scaffolds and the effect of different parameters on the structure of these scaffolds was investigated. To investigate the effect of different factors on gelation, swelling, tensile test, degradability and finally the conditions of fibroplast cell growth on scaffolds were investigated. The results of the gel test showed that the gel was higher than 90% for radiation above 35 kGy. The presence of 1% of nanoparticles resulted in a 2% reduction in gelation. And an increase of 10 kGy resulted in a 3% increase in gel levels. In the swelling test, it was shown that an increase of 10 kGy resulted in a decrease of about 15% in porosity, and the presence of 1% nanoparticles resulted in an increase of about 10% in inflation. In the destructive test, after 15 days, the presence of nanoparticles decreased, and, conversely, an increase of 10 kGy caused a 0.5% increase in degradation rates. The biocompatibility test carried out over a five-day period indicated that PEG's presence reduced biocompatibility. The results of mechanical tensile test showed that the presence of nanoparticles while maintaining yield stress in the samples increased the 6% increase in strain rate of samples, indicating an increase in their strength. Finally, in electronic microscopic images, we found that the presence of 1% of nanoparticles resulted in an increase of 10 micrometers of porosity, so that in the presence of 3% nanoparticles, the porosity reached about 220 micrometers
  9. Keywords:
  10. Poly Vinyl Alcohol ; Gamma Irradiation ; Cellular Porous Scaffold ; Polyethylen Glycol (PEG) ; Polyvinylpyrolidon ; Diamond Nanoparticle ; Tissue Engineering

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