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Analysis of nonlinear acoustic wave propagation in HIFU treatment using westervelt equation

Haddadi, S ; Sharif University of Technology | 2018

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  1. Type of Document: Article
  2. DOI: 10.24200/sci.2017.4496
  3. Publisher: Sharif University of Technology , 2018
  4. Abstract:
  5. Currently, the HIFU (High-Intensity Focused Ultrasound) therapy method is known as one of the most advanced surgical techniques of tumor ablation therapy. Simulation of the non-linear acoustic wave and tissue interaction is essential in HIFU planning to improve the usefulness and efficiency of treatment. In this paper, linear, thermoviscous, and nonlinear equations are applied using two different media: liver and water. Transducer power of 8.3-134 Watts with the frequency of 1.1 MHz is considered as the range of study to analyze the interaction of wave and tissue. Results indicate that the maximum focal pressure of about 0.5-4.3 MPa can be achieved for transducer power rates of 8.3 to 134 W. The simultaneous solving of the acoustic pressure and Pennes's bio-heat equations can help determine the amount of temperature rise at the focal point and ablated area. Finally, the linear and nonlinear simulations are compared, and the turning point of transition from linearity to nonlinearity is determined. The simulated results provide us with the required information about the behavior of the focalized ultrasound in interaction with liver tissue. The performance of phased array HIFU transducer can be improved for treatment considering lesion size as well as temperature rise in tissue and for choosing the best range of operational power. © 2018 Sharif University of Technology. All rights reserved
  6. Keywords:
  7. Pennes's bio-heat equation ; Westervelt equation ; Acoustic wave propagation ; Acoustic waves ; Control nonlinearities ; Heat transfer ; Partial differential equations ; Tissue ; Tissue engineering ; Transducers ; Ultrasonics ; Bio-heat equations ; HIFU ; KZK equation ; Nonlinear wave propagation ; Westervelt equation ; Nonlinear equations ; Acoustic wave ; Array ; Detection method ; Efficiency measurement ; Nonlinearity ; Performance assessment ; Simulation ; Temperature effect ; Transducer ; Wave equation ; Wave propagation
  8. Source: Scientia Iranica ; Volume 25, Issue 4 , 2018 , Pages 2087-2097 ; 10263098 (ISSN)
  9. URL: http://scientiairanica.sharif.edu/article_4496.html