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MicroRNAs 29, 150, 155, 223 level and their relation to viral and immunological markers in HIV-1 infected naive patients

Moghoofei, M ; Sharif University of Technology

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  1. Type of Document: Article
  2. DOI: 10.2217/fvl-2018-0055
  3. Abstract:
  4. Aim: The aim of this study was to assess the relationship between microRNAs and viral and immunological markers in HIV-1 infection. Materials & methods: The expression level of miRNAs was evaluated in 60 HIV-1 patients and 20 healthy controls using real-time PCR assays. Results: The results showed that among all miRNAs, miR-29 and miR-150 were significantly downregulated in HIV-1 patients compared with healthy controls, while miR-155 and miR-223 were significantly upregulated compared with healthy controls (p < 0.001 for all comparisons). Conclusion: The mentioned miRNAs seem to influence the clinical progression of HIV-1 infection in naive patients. Moreover, determining the profiles of miRNAs involved in the pathogenesis of HIV infection and manipulating these miRNAs could lead to opening a new gate to HIV-1 infection control. © 2018 Future Medicine Ltd
  5. Keywords:
  6. HIV-1 ; Naive ; Nef ; PBMC ; Human immunodeficiency virus antibody ; MicroRNA ; MicroRNA 150 ; MicroRNA 155 ; MicroRNA 223 ; MicroRNA 29 ; Nef protein ; Unclassified drug ; Adult ; Case control study ; CD4 lymphocyte count ; CD4+ tlymphocyte ; Clinical assessment ; Density gradient centrifugation ; Female ; Gene expression ; Human ; Human cell ; Human immunodeficiency virus 1 infection ; Human immunodeficiency virus infected patient ; Injection drug user ; Major clinical study ; Male ; Needlestick injury ; Observational study ; Peripheral blood mononuclear cell ; Priority journal ; Real time polymerase chain reaction ; Receptor down regulation ; Serology ; Sexual transmission ; Tattooing ; Transfusion ; Virus load ; Virus transmission
  7. Source: Future Virology ; Volume 13, Issue 9 , 2018 , Pages 637-645 ; 17460794 (ISSN)
  8. URL: https://www.futuremedicine.com/doi/10.2217/fvl-2018-0055