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RSM based engineering of the critical gelation temperature in magneto-thermally responsive nanocarriers

Khodaei, A ; Sharif University of Technology | 2019

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  1. Type of Document: Article
  2. DOI: 10.1016/j.eurpolymj.2019.08.024
  3. Publisher: Elsevier Ltd , 2019
  4. Abstract:
  5. The multistep release of therapeutic agents in the theranostic particulate systems has remained as a challenge in smart drug delivery. In this study, superparamagnetic nanoparticles of Fe3O4 were coated with a blend of F127/F68 grades of pluronic in order to adjust the lower critical solution temperature (LCST) and consequently engineering of the release temperature. Pluronic as a biocompatible thermo-sensitive polymer is frequently used as a self-emulsifying drug delivery system. Magnetite nanoparticles with double layer coating of oleic acid and pluronic F127 have been reported as an on-demand smart carrier for hydrophobic drugs. LCST was examined using differential scanning calorimetry (DSC) and temperature modulated DSC (TMDSC). Response surface methodology (RSM) was also applied for the design of experiments and modelling of LCST as a function of oleic acid content, polymer/particle, and F127/F68 ratio. The oleic acid content was optimized for the synthesis of the most hydrophilic nanocarrier with the highest drug capacity and the model was modified. The model has the advantage to be normalized appropriately to the specific area in various particle sizes. This study led the way for optimizing the LCST behavior in thermos-responsive systems. © 2019 Elsevier Ltd
  6. Keywords:
  7. Lower critical solution temperature (LCST) ; Magnetite nanoparticles ; Modeling ; Pluronic blend ; Biocompatibility ; Controlled drug delivery ; Design of experiments ; Differential scanning calorimetry ; Emulsification ; Gelation ; Iron oxides ; Magnetite ; Magnetite nanoparticles ; Models ; Oleic acid ; Plastic coatings ; Critical gelation temperatures ; Lower critical solution temperature ; Pluronics ; Response surface methodology ; Self-emulsifying drug delivery system ; Superparamagnetic nanoparticles ; Temperature-modulated DSC ; Thermo-sensitive polymer ; Targeted drug delivery
  8. Source: European Polymer Journal ; Volume 120 , 2019 ; 00143057 (ISSN)
  9. URL: https://www.sciencedirect.com/science/article/pii/S0014305719311553