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Targeting AMPK signaling pathway by natural products for treatment of diabetes mellitus and its complications

Joshi, T ; Sharif University of Technology | 2019

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  1. Type of Document: Article
  2. DOI: 10.1002/jcp.28528
  3. Publisher: Wiley-Liss Inc , 2019
  4. Abstract:
  5. Diabetes affects a large population of the world. Lifestyle, obesity, dietary habits, and genetic factors contribute to this metabolic disease. A target pathway to control diabetes is the 5′-adenosine monophosphate-activated protein kinase (AMPK) signaling pathway. AMPK is a heterotrimeric protein with α, β, and γ subunits. In several studies, AMPK activation enhanced glucose uptake into cells and inhibited intracellular glucose production. Impairment of AMPK activity is present in diabetes, according to some studies. Drugs used in the treatment of diabetes, such as metformin, are also known to act through regulation of AMPK. Thus, drugs that activate and regulate AMPK are potential candidates for the treatment of diabetes. In addition, many patients encounter important adverse effects, like hypoglycemia, while using allopathic drugs. As a result, the investigation of plant-derived natural drugs that lack adverse side effects and treat diabetes is necessary. Natural products like berberine, quercetin, resveratrol, and so forth have shown significant potential in regulating and activating the AMPK pathway which can lead to manage diabetes mellitus and its complications. © 2019 Wiley Periodicals, Inc
  6. Keywords:
  7. ACC ; AMP ; AMPK ; Berberine ; Diabetes ; Natural products ; Resveratrol ; Absinthol ; Flavanol derivative ; Flavanone derivative ; Flavone derivative ; Genistein ; Glyceollin ; Hydroxymethylglutaryl coenzyme A reductase kinase ; Natural product ; Phenol derivative ; Quercetin ; Resveratrol ; Salvianolic acid ; Sophoricoside ; Thioctic acid ; Unclassified drug ; AMPK signaling ; Articum lappa ; Aspalathus ; Aspalathus linearis ; Combretum ; Combretum lanceolatum ; Diabetes mellitus ; Diabetic complication ; Diabetic patient ; Enzyme activation ; Human ; Insulin resistance ; Liver ; Medicinal plant ; Priority journal ; Protein structure ; Review ; Skeletal muscle ; Spatholobus suberectus
  8. Source: Journal of Cellular Physiology ; Volume 234, Issue 10 , 2019 , Pages 17212-17231 ; 00219541 (ISSN)
  9. URL: https://onlinelibrary.wiley.com/doi/abs/10.1002/jcp.28528