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Smart magnetic self-assembled micelle: an effective nanocarrier for thermo-triggered paclitaxel delivery

Pourjavadi, A ; Sharif University of Technology | 2019

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  1. Type of Document: Article
  2. DOI: 10.1080/00914037.2018.1493687
  3. Publisher: Taylor and Francis Inc , 2019
  4. Abstract:
  5. Magnetic micelle nanoparticles with thermoresponsive behavior were designed for thermo-triggered paclitaxel delivery. For this purpose, thermoresponsive triblock copolymer poly(N-isopropyl acrylamide)-b-polycaprolactone-b-poly(N-isopropyl acrylamide) was prepared. The magnetic micelle was formed by self-assembly of triblock copolymer on the magnetite which was coated by oleic acid. The size of the magnetic micelle was between 30–40 nm reported by transmission electron microscopy. Also, dynamic light scattering indicated the hydrodynamic diameter was thermal dependent. Moreover, the drug release profile showed thermo-triggered release of paclitaxel. Thus, the smart nanocarrier has potential to be applied in both chemotherapy and hyperthermia treatment. © 2018, © 2018 Taylor & Francis
  6. Keywords:
  7. Micelle ; Thermosensitive ; Triblock copolymer ; Amides ; Block copolymers ; Chemotherapy ; Controlled drug delivery ; High resolution transmission electron microscopy ; Hyperthermia therapy ; Light scattering ; Magnetite ; Micelles ; Nanomagnetics ; Self assembly ; Transmission electron microscopy ; Hydrodynamic diameter ; Hyperthermia treatments ; N-isopropylacrylamides ; Paclitaxel ; Paclitaxel delivery ; Thermo sensitive ; Thermo-responsive behaviors ; Triggered release ; Targeted drug delivery
  8. Source: International Journal of Polymeric Materials and Polymeric Biomaterials ; Volume 68, Issue 12 , 2019 , Pages 741-749 ; 00914037 (ISSN)
  9. URL: https://www.tandfonline.com/doi/abs/10.1080/00914037.2018.1493687?journalCode=gpom20