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Dual-diffusivity stochastic model for macromolecule release from a hydrogel

Jahanmir, G ; Sharif University of Technology | 2020

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  1. Type of Document: Article
  2. DOI: 10.1021/acsabm.0c00293
  3. Publisher: American Chemical Society , 2020
  4. Abstract:
  5. A three-dimensional model has been developed to describe the multiphase release of macromolecular drugs encapsulated in a hydrogel. The heterogeneity of network mesh size was considered by assigning varying diffusion coefficients to the network lattices randomly. Using a stochastic approach, the random nature of diffusion of drug molecules was captured within the network. The simplest form of distribution containing two diffusion coefficients was tested. To generate the drug release profiles for experimental validation under the limitation of computational cost, a simple scaling relationship was employed. Unlike the single-diffusivity model, the dual-diffusivity model showed good agreement with the experimental data in describing the release profiles of macromolecular drugs of three different sizes from chemically cross-linked dextran hydrogels. © 2020 American Chemical Society
  6. Keywords:
  7. Controlled release ; Hydrogel ; Hydrogel network inhomogeneity ; Mathematical modeling ; Stochastic simulation ; Controlled drug delivery ; Diffusion ; Hydrogels ; Macromolecules ; Stochastic systems ; Targeted drug delivery ; Computational costs ; Different sizes ; Experimental validations ; Macromolecular drugs ; Release profiles ; Scaling relationships ; Stochastic approach ; Three-dimensional model ; Stochastic models
  8. Source: ACS Applied Bio Materials ; Volume 3, Issue 7 , 2020 , Pages 4208-4219
  9. URL: https://pubs.acs.org/doi/10.1021/acsabm.0c00293