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Biocompatible conductive alginate/polyaniline-graphene neural conduits fabricated using a facile solution extrusion technique

Bayat, A ; Sharif University of Technology | 2021

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  1. Type of Document: Article
  2. DOI: 10.1080/00914037.2020.1725764
  3. Publisher: Bellwether Publishing, Ltd , 2021
  4. Abstract:
  5. In this study, conductive sodium alginate/polyaniline/graphene (PAG) NGCs were fabricated utilizing a straightforward solution extrusion method. The 4 point-probe test revealed that the addition of PAG has increased the conductivity of the NGCs up to 9.7 × 10−3 S.cm−1. The results also showed a remarkable increase in the Young modulus and SEM images revealed that the suggested process could produce NGCs continuously and uniformly with desirable porosity. The Fourier-transform infrared spectroscopy spectrum proved a good interaction between PAG and the polymeric matrix. Furthermore, the addition of PAG slightly prevented biodegradation of the NGCs. Finally, the cell viability assay confirmed the ability of PAG to stimulate PC12 proliferation. The results corroborated the potential use of NGCs to be applied in nerve tissue engineering applications. © 2020 Taylor & Francis Group, LLC
  6. Keywords:
  7. Biocompatibility ; Biodegradation ; Electric conductivity ; Fabrication ; Fourier transform infrared spectroscopy ; Nanostructured materials ; Sodium alginate ; Tissue engineering ; Biocompatible polymer ; Cell viability assays ; Extrusion method ; Extrusion techniques ; Nerve tissue engineering ; Neural conduits ; Peripheral nerve regeneration ; Polymeric matrices ; Extrusion
  8. Source: International Journal of Polymeric Materials and Polymeric Biomaterials ; Volume 70, Issue 7 , 2021 , Pages 486-495 ; 00914037 (ISSN)
  9. URL: https://www.tandfonline.com/doi/abs/10.1080/00914037.2020.1725764?journalCode=gpom20